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Postantibiotic effect of meropenem and ciprofloxacin in the presence of 5-fluorouracil

Nyhlén, Anna LU ; Ljungberg, Bengt LU ; Nilsson-Ehle, Ingrid LU and Odenholt, Inga LU (2002) In Chemotherapy 48(4). p.182-188
Abstract
Background: The postantibiotic effect (PAE) of meropenem and ciprofloxacin was studied in the presence of the antineoplastic agent 5-fluorouracil (5-FU). The purpose of the study was to investigate whether the PAEs of the combinations differed from the PAEs of the antibiotics alone. Methods: The PAEs of the combinations of 5-FU plus meropenem or ciprofloxacin were determined with viable counts against four reference strains of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli and two clinical isolates of S. epidermidis. The results were compared with the PAEs of the antibiotics drugs and 5-FU alone. The gram-positive strains were tested for slime production, both alone and in the presence of 5-FU.... (More)
Background: The postantibiotic effect (PAE) of meropenem and ciprofloxacin was studied in the presence of the antineoplastic agent 5-fluorouracil (5-FU). The purpose of the study was to investigate whether the PAEs of the combinations differed from the PAEs of the antibiotics alone. Methods: The PAEs of the combinations of 5-FU plus meropenem or ciprofloxacin were determined with viable counts against four reference strains of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli and two clinical isolates of S. epidermidis. The results were compared with the PAEs of the antibiotics drugs and 5-FU alone. The gram-positive strains were tested for slime production, both alone and in the presence of 5-FU. Results: Against two of the three tested strains of S. epidermidis, the combination of ciprofloxacin and 5-FU gave a synergistic prolongation of the PAE in comparison with the PAEs induced by the drugs alone. The combinations showed indifference against the other bacteria. The combination of meropenem and 5-FU had a synergistic PAE against one of the three tested strains of S. epidermidis and an additive effect against E coli but showed indifference against the rest of the strains. Conclusions:The presence of 5-FU did not influence the PAEs of the antibiotics against most of the tested strains, but caused a synergistic prolongation of the PAEs induced by ciprofloxacin and meropenem against some of the tested strains of S. epidermidis. 5-FU inhibited slime production in the same S. epidermidis strains, which might have contributed to the longer PAE. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytostatic drugs, antibiotics, postantibiotic effect, pharmacodynamics, biofilm, synergy
in
Chemotherapy
volume
48
issue
4
pages
182 - 188
publisher
Karger
external identifiers
  • wos:000178431100005
  • scopus:0036727563
ISSN
0009-3157
language
English
LU publication?
yes
id
bcd2d852-9bde-4ec2-8cb1-4a254a64c21a (old id 326209)
alternative location
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=63872&ProduktNr=223834&Ausgabe=228498&filename=63872.pdf
date added to LUP
2007-11-02 13:43:06
date last changed
2017-01-01 06:44:24
@article{bcd2d852-9bde-4ec2-8cb1-4a254a64c21a,
  abstract     = {Background: The postantibiotic effect (PAE) of meropenem and ciprofloxacin was studied in the presence of the antineoplastic agent 5-fluorouracil (5-FU). The purpose of the study was to investigate whether the PAEs of the combinations differed from the PAEs of the antibiotics alone. Methods: The PAEs of the combinations of 5-FU plus meropenem or ciprofloxacin were determined with viable counts against four reference strains of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli and two clinical isolates of S. epidermidis. The results were compared with the PAEs of the antibiotics drugs and 5-FU alone. The gram-positive strains were tested for slime production, both alone and in the presence of 5-FU. Results: Against two of the three tested strains of S. epidermidis, the combination of ciprofloxacin and 5-FU gave a synergistic prolongation of the PAE in comparison with the PAEs induced by the drugs alone. The combinations showed indifference against the other bacteria. The combination of meropenem and 5-FU had a synergistic PAE against one of the three tested strains of S. epidermidis and an additive effect against E coli but showed indifference against the rest of the strains. Conclusions:The presence of 5-FU did not influence the PAEs of the antibiotics against most of the tested strains, but caused a synergistic prolongation of the PAEs induced by ciprofloxacin and meropenem against some of the tested strains of S. epidermidis. 5-FU inhibited slime production in the same S. epidermidis strains, which might have contributed to the longer PAE.},
  author       = {Nyhlén, Anna and Ljungberg, Bengt and Nilsson-Ehle, Ingrid and Odenholt, Inga},
  issn         = {0009-3157},
  keyword      = {cytostatic drugs,antibiotics,postantibiotic effect,pharmacodynamics,biofilm,synergy},
  language     = {eng},
  number       = {4},
  pages        = {182--188},
  publisher    = {Karger},
  series       = {Chemotherapy},
  title        = {Postantibiotic effect of meropenem and ciprofloxacin in the presence of 5-fluorouracil},
  volume       = {48},
  year         = {2002},
}