Advanced

Experimental pancreatitis causes acute perturbation of energy metabolism in the intestinal wall

Ederoth, Per LU ; Sun, Zhengwu LU ; Nordström, Carl-Henrik LU and Andersson, Roland LU (2002) In Pancreas 25(3). p.270-276
Abstract
Introduction: The systemic inflammatory response syndrome (SIRS) may be initiated by a number of underlying conditions such as acute pancreatitis. The association between the local inflammatory reaction, the systemic response, and potential concomitant dysfunction of remote organs is not quite clear. Aim: To evaluate whether severe acute pancreatitis in the rat affects energy metabolism in the pancreas and whether the focal inflammation also causes biochemical deterioration in remote organs such as the liver and intestine. Methodology: With the patient under general anesthesia, microdialysis probes were inserted in the pancreas, liver, and small intestine. Two groups of eight rats each were studied: the sham (control) group and the... (More)
Introduction: The systemic inflammatory response syndrome (SIRS) may be initiated by a number of underlying conditions such as acute pancreatitis. The association between the local inflammatory reaction, the systemic response, and potential concomitant dysfunction of remote organs is not quite clear. Aim: To evaluate whether severe acute pancreatitis in the rat affects energy metabolism in the pancreas and whether the focal inflammation also causes biochemical deterioration in remote organs such as the liver and intestine. Methodology: With the patient under general anesthesia, microdialysis probes were inserted in the pancreas, liver, and small intestine. Two groups of eight rats each were studied: the sham (control) group and the pancreatitis group. Acute pancreatitis was induced by intraductal injection of 5% sodium taurodeoxycholate, and the animals were studied for 3 hours thereafter. The microdialysis fluid was analyzed for glucose, lactate, and pyruvate. Results: In the pancreatitis group we found significant increases in glucose concentration in the pancreas and lactate levels in the pancreas and intestinal wall, and the lactate/pyruvate ratio was significantly higher in the intestine than in the sham group. Conclusion: Induction of severe acute pancreatitis results in immediate metabolic alterations in the pancreas. In the intestinal wall a severe perturbation of energy metabolism is observed after only 1 hour. This implies a rapid onset of metabolic disturbances, not only in the local, challenged organ (pancreas) but also in remote organs. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pancreatitis, rats, multiple organ failure, energy metabolism, microdialysis
in
Pancreas
volume
25
issue
3
pages
270 - 276
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:12370538
  • wos:000178259400009
  • scopus:0036785143
ISSN
0885-3177
language
English
LU publication?
yes
id
7fbb5ca4-ff65-4bf0-841b-5ae1fd23a46b (old id 326349)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12370538&dopt=AbstractPlus
date added to LUP
2007-08-16 11:13:12
date last changed
2017-01-01 04:57:37
@article{7fbb5ca4-ff65-4bf0-841b-5ae1fd23a46b,
  abstract     = {Introduction: The systemic inflammatory response syndrome (SIRS) may be initiated by a number of underlying conditions such as acute pancreatitis. The association between the local inflammatory reaction, the systemic response, and potential concomitant dysfunction of remote organs is not quite clear. Aim: To evaluate whether severe acute pancreatitis in the rat affects energy metabolism in the pancreas and whether the focal inflammation also causes biochemical deterioration in remote organs such as the liver and intestine. Methodology: With the patient under general anesthesia, microdialysis probes were inserted in the pancreas, liver, and small intestine. Two groups of eight rats each were studied: the sham (control) group and the pancreatitis group. Acute pancreatitis was induced by intraductal injection of 5% sodium taurodeoxycholate, and the animals were studied for 3 hours thereafter. The microdialysis fluid was analyzed for glucose, lactate, and pyruvate. Results: In the pancreatitis group we found significant increases in glucose concentration in the pancreas and lactate levels in the pancreas and intestinal wall, and the lactate/pyruvate ratio was significantly higher in the intestine than in the sham group. Conclusion: Induction of severe acute pancreatitis results in immediate metabolic alterations in the pancreas. In the intestinal wall a severe perturbation of energy metabolism is observed after only 1 hour. This implies a rapid onset of metabolic disturbances, not only in the local, challenged organ (pancreas) but also in remote organs.},
  author       = {Ederoth, Per and Sun, Zhengwu and Nordström, Carl-Henrik and Andersson, Roland},
  issn         = {0885-3177},
  keyword      = {pancreatitis,rats,multiple organ failure,energy metabolism,microdialysis},
  language     = {eng},
  number       = {3},
  pages        = {270--276},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Experimental pancreatitis causes acute perturbation of energy metabolism in the intestinal wall},
  volume       = {25},
  year         = {2002},
}