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Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment

Haapaniemi, T; Nishiura, Y and Dahlin, Lars LU (2002) In Journal of the Peripheral Nervous System 7(3). p.149-154
Abstract
Previous experimental studies have shown positive effects of hyperbaric oxygen treatment in the early regeneration phase in the first few days following a nerve injury. In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. Postoperatively the animals were treated with 100% oxygen at 2.5 atmospheres absolute pressure for 90 minutes and the treatment was employed twice daily for 7 days. The animals were evaluated with walking track analysis up to twice weekly. The experiments were terminated after 90 days when the tetanic force was measured in the tibial anterior and gastrocnemius... (More)
Previous experimental studies have shown positive effects of hyperbaric oxygen treatment in the early regeneration phase in the first few days following a nerve injury. In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. Postoperatively the animals were treated with 100% oxygen at 2.5 atmospheres absolute pressure for 90 minutes and the treatment was employed twice daily for 7 days. The animals were evaluated with walking track analysis up to twice weekly. The experiments were terminated after 90 days when the tetanic force was measured in the tibial anterior and gastrocnemius muscles. No statistically significant differences were found in either of these tests. It is concluded that hyperbaric oxygen treatment, given in accordance with clinical protocols used in limb crush injuries and other peripheral conditions, was not effective in the restoration of gait or the muscular strength after 90 days in rats after these nerve injuries. This study does not support nerve crush injury or nerve transection and repair as indications for hyperbaric oxygen treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tetanic force, analysis, walking track, hyperbaric oxygenation, nerve injury, nerve repair
in
Journal of the Peripheral Nervous System
volume
7
issue
3
pages
149 - 154
publisher
Wiley-Blackwell
external identifiers
  • pmid:12365562
  • wos:000178254000003
  • scopus:0036737832
ISSN
1085-9489
DOI
10.1046/j.1529-8027.2002.02021.x
language
English
LU publication?
yes
id
0ca3d7c8-0828-469a-a366-fb0da98711a8 (old id 326384)
date added to LUP
2007-08-22 14:48:28
date last changed
2017-10-29 04:26:01
@article{0ca3d7c8-0828-469a-a366-fb0da98711a8,
  abstract     = {Previous experimental studies have shown positive effects of hyperbaric oxygen treatment in the early regeneration phase in the first few days following a nerve injury. In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. Postoperatively the animals were treated with 100% oxygen at 2.5 atmospheres absolute pressure for 90 minutes and the treatment was employed twice daily for 7 days. The animals were evaluated with walking track analysis up to twice weekly. The experiments were terminated after 90 days when the tetanic force was measured in the tibial anterior and gastrocnemius muscles. No statistically significant differences were found in either of these tests. It is concluded that hyperbaric oxygen treatment, given in accordance with clinical protocols used in limb crush injuries and other peripheral conditions, was not effective in the restoration of gait or the muscular strength after 90 days in rats after these nerve injuries. This study does not support nerve crush injury or nerve transection and repair as indications for hyperbaric oxygen treatment.},
  author       = {Haapaniemi, T and Nishiura, Y and Dahlin, Lars},
  issn         = {1085-9489},
  keyword      = {tetanic force,analysis,walking track,hyperbaric oxygenation,nerve injury,nerve repair},
  language     = {eng},
  number       = {3},
  pages        = {149--154},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the Peripheral Nervous System},
  title        = {Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment},
  url          = {http://dx.doi.org/10.1046/j.1529-8027.2002.02021.x},
  volume       = {7},
  year         = {2002},
}