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Personalised advanced therapies in parkinson’s disease : The role of non-motor symptoms profile

Leta, Valentina ; Dafsari, Haidar S. ; Sauerbier, Anna ; Metta, Vinod ; Titova, Nataliya ; Timmermann, Lars ; Ashkan, Keyoumars ; Samuel, Michael ; Pekkonen, Eero and Odin, Per LU orcid , et al. (2021) In Journal of Personalized Medicine 11(8).
Abstract

Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson’s disease (PD). Currently, selection of device-aided therapies is mainly focused on patients’ motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that... (More)

Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson’s disease (PD). Currently, selection of device-aided therapies is mainly focused on patients’ motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apomorphine, Deep brain stimulation, Device-aided therapies, Levodopa-carbidopa intestinal gel, Non-motor symptoms, Parkinson’s disease, Personalised medicine
in
Journal of Personalized Medicine
volume
11
issue
8
article number
773
publisher
MDPI AG
external identifiers
  • pmid:34442417
  • scopus:85113773139
ISSN
2075-4426
DOI
10.3390/jpm11080773
language
English
LU publication?
yes
id
32655448-8f0a-4147-a334-8d7c0fdb0465
date added to LUP
2021-09-20 15:35:38
date last changed
2025-03-10 21:54:04
@article{32655448-8f0a-4147-a334-8d7c0fdb0465,
  abstract     = {{<p>Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson’s disease (PD). Currently, selection of device-aided therapies is mainly focused on patients’ motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.</p>}},
  author       = {{Leta, Valentina and Dafsari, Haidar S. and Sauerbier, Anna and Metta, Vinod and Titova, Nataliya and Timmermann, Lars and Ashkan, Keyoumars and Samuel, Michael and Pekkonen, Eero and Odin, Per and Antonini, Angelo and Martinez-Martin, Pablo and Parry, Miriam and Van Wamelen, Daniel J. and Ray Chaudhuri, K.}},
  issn         = {{2075-4426}},
  keywords     = {{Apomorphine; Deep brain stimulation; Device-aided therapies; Levodopa-carbidopa intestinal gel; Non-motor symptoms; Parkinson’s disease; Personalised medicine}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Personalized Medicine}},
  title        = {{Personalised advanced therapies in parkinson’s disease : The role of non-motor symptoms profile}},
  url          = {{http://dx.doi.org/10.3390/jpm11080773}},
  doi          = {{10.3390/jpm11080773}},
  volume       = {{11}},
  year         = {{2021}},
}