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Nanoparticles as pseudostationary phase in capillary electrochrornatography/ESI-MS

Viberg, Peter LU ; Jornten-Karlsson, M; Petersson, P; Spégel, Peter LU and Nilsson, Staffan LU (2002) In Analytical Chemistry 74(18). p.4595-4601
Abstract
A novel technique that uses polymer nanoparticles as pseudostationary phase in capillary electrochromatography with electrospray ionization mass spectrometry detection is described. A continuous full filling technique in which the nanoparticles were suspended in the entire electrolyte volume as well as a conventional partial filling technique is presented. No nanoparticles entered the mass spectrometer, which was fitted with an orthogonal electrospray interface, despite the continuous flow of nanoparticles into the interface. Nanoparticles (average diameter 160 nm) were prepared from methacrylic acid, methyl methacrylate, and trimethylolpropane trimethacrylate by utilizing a precipitation polymerization technique. Salbutamol,... (More)
A novel technique that uses polymer nanoparticles as pseudostationary phase in capillary electrochromatography with electrospray ionization mass spectrometry detection is described. A continuous full filling technique in which the nanoparticles were suspended in the entire electrolyte volume as well as a conventional partial filling technique is presented. No nanoparticles entered the mass spectrometer, which was fitted with an orthogonal electrospray interface, despite the continuous flow of nanoparticles into the interface. Nanoparticles (average diameter 160 nm) were prepared from methacrylic acid, methyl methacrylate, and trimethylolpropane trimethacrylate by utilizing a precipitation polymerization technique. Salbutamol, nortriptyline, and diphenhydramine were used as analytes. The interaction between analytes and nanoparticles was found to be predominantly ionic. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
74
issue
18
pages
4595 - 4601
publisher
The American Chemical Society
external identifiers
  • pmid:12349959
  • wos:000178068000001
  • scopus:0037106390
ISSN
1520-6882
DOI
10.1021/ac0204045
language
English
LU publication?
yes
id
d99ef15c-e50d-49e7-85be-7a251e835e10 (old id 327689)
date added to LUP
2007-11-19 08:38:28
date last changed
2017-12-03 03:24:44
@article{d99ef15c-e50d-49e7-85be-7a251e835e10,
  abstract     = {A novel technique that uses polymer nanoparticles as pseudostationary phase in capillary electrochromatography with electrospray ionization mass spectrometry detection is described. A continuous full filling technique in which the nanoparticles were suspended in the entire electrolyte volume as well as a conventional partial filling technique is presented. No nanoparticles entered the mass spectrometer, which was fitted with an orthogonal electrospray interface, despite the continuous flow of nanoparticles into the interface. Nanoparticles (average diameter 160 nm) were prepared from methacrylic acid, methyl methacrylate, and trimethylolpropane trimethacrylate by utilizing a precipitation polymerization technique. Salbutamol, nortriptyline, and diphenhydramine were used as analytes. The interaction between analytes and nanoparticles was found to be predominantly ionic.},
  author       = {Viberg, Peter and Jornten-Karlsson, M and Petersson, P and Spégel, Peter and Nilsson, Staffan},
  issn         = {1520-6882},
  language     = {eng},
  number       = {18},
  pages        = {4595--4601},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Nanoparticles as pseudostationary phase in capillary electrochrornatography/ESI-MS},
  url          = {http://dx.doi.org/10.1021/ac0204045},
  volume       = {74},
  year         = {2002},
}