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Use of folic acid and delivery outcome: a prospective registry study

Källén, Bengt LU and Olausson, PO (2002) In Reproductive Toxicology 16(4). p.327-332
Abstract
Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the... (More)
Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the literature on the beneficial effect of folic acid in preventing congenital malformations, especially of a non-neural tube defect type. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
orofacial clefts, hypospadias, congenital malformations, neural tube defects, folic acid, prophylaxis, anal atresia, cardiac defects
in
Reproductive Toxicology
volume
16
issue
4
pages
327 - 332
publisher
Elsevier
external identifiers
  • wos:000178206100001
  • scopus:0036655312
ISSN
1873-1708
DOI
10.1016/S0890-6238(02)00041-2
language
English
LU publication?
yes
id
882027f3-eb98-4577-b44f-c6009d4fbd42 (old id 327846)
date added to LUP
2007-11-07 12:34:29
date last changed
2017-02-22 10:46:48
@article{882027f3-eb98-4577-b44f-c6009d4fbd42,
  abstract     = {Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the literature on the beneficial effect of folic acid in preventing congenital malformations, especially of a non-neural tube defect type.},
  author       = {Källén, Bengt and Olausson, PO},
  issn         = {1873-1708},
  keyword      = {orofacial clefts,hypospadias,congenital malformations,neural tube defects,folic acid,prophylaxis,anal atresia,cardiac defects},
  language     = {eng},
  number       = {4},
  pages        = {327--332},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Use of folic acid and delivery outcome: a prospective registry study},
  url          = {http://dx.doi.org/10.1016/S0890-6238(02)00041-2},
  volume       = {16},
  year         = {2002},
}