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Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

Gonzalez, Carlos A.; Lujan-Barroso, Leila; Bueno-de-Mesquita, H. B. (as); Jenab, Mazda; Duell, Eric J.; Agudo, Antonio; Tjonneland, Anne; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise and Touillaud, Marina, et al. (2012) In International Journal of Cancer 131(12). p.2910-2919
Abstract
In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a subsample was used to correct for dietary measurement errors. When comparing the... (More)
In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a subsample was used to correct for dietary measurement errors. When comparing the highest vs. lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk [hazard ratio (HR) 0.77; 95% confidence interval (CI) 0.571.04; p for trend 0.02], between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.360.97; p for trend 0.03) and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.381.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations, none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC, respectively. (Less)
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published
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keywords
gastric cancer, fruit and vegetables, cohort study
in
International Journal of Cancer
volume
131
issue
12
pages
2910 - 2919
publisher
John Wiley & Sons
external identifiers
  • wos:000310482300020
  • scopus:84867886475
ISSN
0020-7136
DOI
10.1002/ijc.27565
language
English
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dab4f5ef-1cb4-476e-b2d5-4d7e0d66d607 (old id 3283297)
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2013-01-07 09:40:15
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@article{dab4f5ef-1cb4-476e-b2d5-4d7e0d66d607,
  abstract     = {In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a subsample was used to correct for dietary measurement errors. When comparing the highest vs. lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk [hazard ratio (HR) 0.77; 95% confidence interval (CI) 0.571.04; p for trend 0.02], between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.360.97; p for trend 0.03) and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.381.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations, none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC, respectively.},
  author       = {Gonzalez, Carlos A. and Lujan-Barroso, Leila and Bueno-de-Mesquita, H. B. (as) and Jenab, Mazda and Duell, Eric J. and Agudo, Antonio and Tjonneland, Anne and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Touillaud, Marina and Teucher, Birgit and Kaaks, Rudolf and Boeing, Heiner and Steffen, Annika and Trichopoulou, Antonia and Roukos, Dimitrios and Karapetyan, Tina and Palli, Domenico and Tagliabue, Giovanna and Mattiello, Amalia and Tumino, Rosario and Ricceri, Fulvio and Siersema, Peter D. and Numans, Mattijs E. and Peeters, Petra P. H. and Parr, Christine L. and Skeie, Guri and Lund, Eiliv and Ramon Quiros, J. and Sanchez-Cantalejo, Emilio and Navarro, Carmen and Barricarte, Aurelio and Dorronsoro, Miren and Ehrnstrom, Roy and Regnér, Sara and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy J. and Crowe, Francesca L. and Blaker, Hendrik and Romieu, Isabelle and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {gastric cancer,fruit and vegetables,cohort study},
  language     = {eng},
  number       = {12},
  pages        = {2910--2919},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up},
  url          = {http://dx.doi.org/10.1002/ijc.27565},
  volume       = {131},
  year         = {2012},
}