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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Orr, Nick; Lemnrau, Alina; Cooke, Rosie; Fletcher, Olivia; Tomczyk, Katarzyna; Jones, Michael; Johnson, Nichola; Lord, Christopher J.; Mitsopoulos, Costas and Zvelebil, Marketa, et al. (2012) In Nature Genetics 44(11). p.1182-1184
Abstract
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
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publication status
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Nature Genetics
volume
44
issue
11
pages
1182 - 1184
publisher
Nature Publishing Group
external identifiers
  • wos:000310495800006
  • scopus:84868207237
ISSN
1546-1718
DOI
10.1038/ng.2417
language
English
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yes
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72773106-a12e-4cbb-8a5e-550403775f69 (old id 3283699)
date added to LUP
2013-01-07 09:41:38
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2017-11-12 03:48:11
@article{72773106-a12e-4cbb-8a5e-550403775f69,
  abstract     = {We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).},
  author       = {Orr, Nick and Lemnrau, Alina and Cooke, Rosie and Fletcher, Olivia and Tomczyk, Katarzyna and Jones, Michael and Johnson, Nichola and Lord, Christopher J. and Mitsopoulos, Costas and Zvelebil, Marketa and McDade, Simon S. and Buck, Gemma and Blancher, Christine and Trainer, Alison H. and James, Paul A. and Bojesen, Stig E. and Bokmand, Susanne and Nevanlinna, Heli and Mattson, Johanna and Friedman, Eitan and Laitman, Yael and Palli, Domenico and Masala, Giovanna and Zanna, Ines and Ottini, Laura and Giannini, Giuseppe and Hollestelle, Antoinette and van den Ouweland, Ans M. W. and Novakovic, Srdjan and Krajc, Mateja and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Olsson, Håkan and Hedenfalk, Ingrid and Easton, Douglas F. and Pharoah, Paul D. P. and Dunning, Alison M. and Bishop, D. Timothy and Neuhausen, Susan L. and Steele, Linda and Houlston, Richard S. and Garcia-Closas, Montserrat and Ashworth, Alan and Swerdlow, Anthony J.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {11},
  pages        = {1182--1184},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk},
  url          = {http://dx.doi.org/10.1038/ng.2417},
  volume       = {44},
  year         = {2012},
}