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Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum

Rosenberg, P; Andersson, H; Boman, K; Ridderheim, Mona LU ; Sorbe, B; Puistola, U and Paro, G (2002) In Acta Oncologica 41(5). p.418-424
Abstract
The aim of this study was to evaluate the efficacy and toxicity of paclitaxel given at the same dose intensity and administered weekly (arm A) or every 3 weeks (arm B), and to assess the safety of intravenous steroids versus standard peroral premedication. Two hundred and eight patients with advanced ovarian cancer previously treated with no more than one platinum-containing regimen were randomized to receive either a weekly infusion of paclitaxel or an infusion every 3 weeks. The median delivered dose intensity was 77.6 mg/m(2)/week in the weekly arm, and 72.7 mg/m(2)/week in the every 3 weeks arm. WHO grade 3-4 hematological and non-hematological toxicity occurred more frequently in arm B. No difference in number of severe events of... (More)
The aim of this study was to evaluate the efficacy and toxicity of paclitaxel given at the same dose intensity and administered weekly (arm A) or every 3 weeks (arm B), and to assess the safety of intravenous steroids versus standard peroral premedication. Two hundred and eight patients with advanced ovarian cancer previously treated with no more than one platinum-containing regimen were randomized to receive either a weekly infusion of paclitaxel or an infusion every 3 weeks. The median delivered dose intensity was 77.6 mg/m(2)/week in the weekly arm, and 72.7 mg/m(2)/week in the every 3 weeks arm. WHO grade 3-4 hematological and non-hematological toxicity occurred more frequently in arm B. No difference in number of severe events of hypersensitivity, response rate, time to progression or survival between arms was observed. Weekly paclitaxel at a dose of 67 mg/m(2)/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks. Intravenous steroids are a safe alternative to oral steroids. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
41
issue
5
pages
418 - 424
publisher
Taylor & Francis
external identifiers
  • pmid:12442916
  • wos:000178147200001
  • scopus:0036407202
ISSN
1651-226X
DOI
10.1080/028418602320404998
language
English
LU publication?
yes
id
a5578169-661f-4f74-9aca-e077decead4b (old id 328469)
date added to LUP
2007-11-12 12:42:34
date last changed
2017-11-26 03:44:32
@article{a5578169-661f-4f74-9aca-e077decead4b,
  abstract     = {The aim of this study was to evaluate the efficacy and toxicity of paclitaxel given at the same dose intensity and administered weekly (arm A) or every 3 weeks (arm B), and to assess the safety of intravenous steroids versus standard peroral premedication. Two hundred and eight patients with advanced ovarian cancer previously treated with no more than one platinum-containing regimen were randomized to receive either a weekly infusion of paclitaxel or an infusion every 3 weeks. The median delivered dose intensity was 77.6 mg/m(2)/week in the weekly arm, and 72.7 mg/m(2)/week in the every 3 weeks arm. WHO grade 3-4 hematological and non-hematological toxicity occurred more frequently in arm B. No difference in number of severe events of hypersensitivity, response rate, time to progression or survival between arms was observed. Weekly paclitaxel at a dose of 67 mg/m(2)/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks. Intravenous steroids are a safe alternative to oral steroids.},
  author       = {Rosenberg, P and Andersson, H and Boman, K and Ridderheim, Mona and Sorbe, B and Puistola, U and Paro, G},
  issn         = {1651-226X},
  language     = {eng},
  number       = {5},
  pages        = {418--424},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum},
  url          = {http://dx.doi.org/10.1080/028418602320404998},
  volume       = {41},
  year         = {2002},
}