Grainyhead-like 2 in development and cancer
(2017) In Tumor Biology 39(5).- Abstract
Grainyhead-like 2 is a human homolog of Drosophila grainyhead. It inhibits epithelial-to-mesenchymal transition that is necessary for cell migration, and it is involved in neural tube closure, epithelial morphogenesis, and barrier formation during embryogenesis by regulation of the expression of cell junction proteins such as E-cadherin and vimentin. Cancer shares many common characters with development such as epithelial-to-mesenchymal transition. In addition to its important role in development, grainyhead-like 2 is implicated in carcinogenesis as well. However, the reports on grainyhead-like 2 in various cancers are controversial. Grainyhead-like 2 can act as either a tumor suppressor or an oncogene with the mechanisms not well... (More)
Grainyhead-like 2 is a human homolog of Drosophila grainyhead. It inhibits epithelial-to-mesenchymal transition that is necessary for cell migration, and it is involved in neural tube closure, epithelial morphogenesis, and barrier formation during embryogenesis by regulation of the expression of cell junction proteins such as E-cadherin and vimentin. Cancer shares many common characters with development such as epithelial-to-mesenchymal transition. In addition to its important role in development, grainyhead-like 2 is implicated in carcinogenesis as well. However, the reports on grainyhead-like 2 in various cancers are controversial. Grainyhead-like 2 can act as either a tumor suppressor or an oncogene with the mechanisms not well elucidated. In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.
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- author
- Ma, Lijun ; Yan, Hongli ; Zhao, Hui and Sun, Jianmin LU
- organization
- publishing date
- 2017-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- E-cadherin, Epithelial-to-mesenchymal transition, Metastasis, Oncogene, Tumor suppressor
- in
- Tumor Biology
- volume
- 39
- issue
- 5
- pages
- 6 pages
- publisher
- Springer
- external identifiers
-
- pmid:28459369
- wos:000407117400001
- scopus:85019969131
- ISSN
- 1010-4283
- DOI
- 10.1177/1010428317698375
- language
- English
- LU publication?
- yes
- id
- 32efa50b-14d8-4607-9d3c-0bf2f1e0564a
- date added to LUP
- 2017-06-30 10:18:55
- date last changed
- 2025-04-04 14:19:33
@article{32efa50b-14d8-4607-9d3c-0bf2f1e0564a,
abstract = {{<p>Grainyhead-like 2 is a human homolog of Drosophila grainyhead. It inhibits epithelial-to-mesenchymal transition that is necessary for cell migration, and it is involved in neural tube closure, epithelial morphogenesis, and barrier formation during embryogenesis by regulation of the expression of cell junction proteins such as E-cadherin and vimentin. Cancer shares many common characters with development such as epithelial-to-mesenchymal transition. In addition to its important role in development, grainyhead-like 2 is implicated in carcinogenesis as well. However, the reports on grainyhead-like 2 in various cancers are controversial. Grainyhead-like 2 can act as either a tumor suppressor or an oncogene with the mechanisms not well elucidated. In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.</p>}},
author = {{Ma, Lijun and Yan, Hongli and Zhao, Hui and Sun, Jianmin}},
issn = {{1010-4283}},
keywords = {{E-cadherin; Epithelial-to-mesenchymal transition; Metastasis; Oncogene; Tumor suppressor}},
language = {{eng}},
number = {{5}},
publisher = {{Springer}},
series = {{Tumor Biology}},
title = {{Grainyhead-like 2 in development and cancer}},
url = {{http://dx.doi.org/10.1177/1010428317698375}},
doi = {{10.1177/1010428317698375}},
volume = {{39}},
year = {{2017}},
}