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A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

Akesson, E; Oturai, A; Berg, J; Fredrikson, S; Andersen, O; Harbo, HF; Laaksonen, M; Myhr, KM; Nyland, HI and Ryder, LP, et al. (2002) In Genes and Immunity 3(5). p.279-285
Abstract
Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3,... (More)
Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis. (Less)
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Contribution to journal
publication status
published
subject
keywords
multiple sclerosis, linkage, susceptibility gene
in
Genes and Immunity
volume
3
issue
5
pages
279 - 285
publisher
Nature Publishing Group
external identifiers
  • wos:000177380000005
  • pmid:12140746
  • scopus:0036691491
ISSN
1476-5470
DOI
10.1038/sj.gene.6363866
language
English
LU publication?
yes
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364310e3-6fa7-4742-a89e-bb9939c016be (old id 331687)
date added to LUP
2007-08-02 10:40:38
date last changed
2017-01-01 04:27:05
@article{364310e3-6fa7-4742-a89e-bb9939c016be,
  abstract     = {Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.},
  author       = {Akesson, E and Oturai, A and Berg, J and Fredrikson, S and Andersen, O and Harbo, HF and Laaksonen, M and Myhr, KM and Nyland, HI and Ryder, LP and Sandberg Wollheim, Magnhild and Sorensen, PS and Spurkland, A and Svejgaard, A and Holmans, P and Compston, A and Hillert, J and Sawcer, S},
  issn         = {1476-5470},
  keyword      = {multiple sclerosis,linkage,susceptibility gene},
  language     = {eng},
  number       = {5},
  pages        = {279--285},
  publisher    = {Nature Publishing Group},
  series       = {Genes and Immunity},
  title        = {A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis},
  url          = {http://dx.doi.org/10.1038/sj.gene.6363866},
  volume       = {3},
  year         = {2002},
}