Flow-through picoliter dispenser: A new approach for solvent elimination in FT-IR spectroscopy
(2002) In Applied Spectroscopy 56(7). p.902-908- Abstract
- A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-through microdispenser as a possible interface for flow system-FT-IR analysis has the capability of meeting the demands of hyphenated miniaturized liquid handling systems (e.g., mu-HPLC, microhigh performance liquid chromatography), as it successfully provides highly stable, reliable and reproducible operating conditions for liquid handling in the... (More)
- A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-through microdispenser as a possible interface for flow system-FT-IR analysis has the capability of meeting the demands of hyphenated miniaturized liquid handling systems (e.g., mu-HPLC, microhigh performance liquid chromatography), as it successfully provides highly stable, reliable and reproducible operating conditions for liquid handling in the picoliter range. Moreover, an increase in sensitivity for FT-IR measurements could be achieved, lowering the mass detection limit of sugars (such as the investigated sucrose) to 53 picograms. As is demonstrated on the example of an HPLC separation of a mixture of glucose and fructose, interfacing LC systems to FT-IR using a piezoactuated flow-through microdispenser is a feasible and promising approach. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/332457
- author
- Haberkorn, M ; Frank, J ; Harasek, M ; Nilsson, Johan LU ; Laurell, Thomas LU and Lendl, B
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- micro-liquid handling, FT-IR, infrared spectroscopy, Fourier transform, flow-through microdispenser, solvent elimination
- in
- Applied Spectroscopy
- volume
- 56
- issue
- 7
- pages
- 902 - 908
- publisher
- Society for Applied Spectroscopy
- external identifiers
-
- wos:000177139500015
- scopus:0036649651
- ISSN
- 1943-3530
- DOI
- 10.1366/000370202760171581
- language
- English
- LU publication?
- yes
- id
- be39a9f0-70e1-4339-aa16-7cd53d48c28c (old id 332457)
- date added to LUP
- 2016-04-01 12:26:53
- date last changed
- 2022-03-29 01:02:41
@article{be39a9f0-70e1-4339-aa16-7cd53d48c28c,
abstract = {{A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-through microdispenser as a possible interface for flow system-FT-IR analysis has the capability of meeting the demands of hyphenated miniaturized liquid handling systems (e.g., mu-HPLC, microhigh performance liquid chromatography), as it successfully provides highly stable, reliable and reproducible operating conditions for liquid handling in the picoliter range. Moreover, an increase in sensitivity for FT-IR measurements could be achieved, lowering the mass detection limit of sugars (such as the investigated sucrose) to 53 picograms. As is demonstrated on the example of an HPLC separation of a mixture of glucose and fructose, interfacing LC systems to FT-IR using a piezoactuated flow-through microdispenser is a feasible and promising approach.}},
author = {{Haberkorn, M and Frank, J and Harasek, M and Nilsson, Johan and Laurell, Thomas and Lendl, B}},
issn = {{1943-3530}},
keywords = {{micro-liquid handling; FT-IR; infrared spectroscopy; Fourier transform; flow-through microdispenser; solvent elimination}},
language = {{eng}},
number = {{7}},
pages = {{902--908}},
publisher = {{Society for Applied Spectroscopy}},
series = {{Applied Spectroscopy}},
title = {{Flow-through picoliter dispenser: A new approach for solvent elimination in FT-IR spectroscopy}},
url = {{http://dx.doi.org/10.1366/000370202760171581}},
doi = {{10.1366/000370202760171581}},
volume = {{56}},
year = {{2002}},
}