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New approaches for brain repair-from rescue to reprogramming

Barker, Roger A LU ; Götz, Magdalena and Parmar, Malin LU orcid (2018) In Nature 557(7705). p.329-334
Abstract

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Brain/cytology, Cellular Reprogramming/physiology, Fetal Tissue Transplantation, Humans, Nerve Regeneration/physiology, Neurodegenerative Diseases/pathology, Regenerative Medicine/methods, Stem Cell Transplantation
in
Nature
volume
557
issue
7705
pages
329 - 334
publisher
Nature Publishing Group
external identifiers
  • pmid:29769670
  • scopus:85047166027
ISSN
0028-0836
DOI
10.1038/s41586-018-0087-1
language
English
LU publication?
yes
id
332a9d4a-a970-4159-885d-351731fae913
date added to LUP
2019-03-21 15:28:50
date last changed
2024-04-30 03:07:41
@article{332a9d4a-a970-4159-885d-351731fae913,
  abstract     = {{<p>The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.</p>}},
  author       = {{Barker, Roger A and Götz, Magdalena and Parmar, Malin}},
  issn         = {{0028-0836}},
  keywords     = {{Animals; Brain/cytology; Cellular Reprogramming/physiology; Fetal Tissue Transplantation; Humans; Nerve Regeneration/physiology; Neurodegenerative Diseases/pathology; Regenerative Medicine/methods; Stem Cell Transplantation}},
  language     = {{eng}},
  number       = {{7705}},
  pages        = {{329--334}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature}},
  title        = {{New approaches for brain repair-from rescue to reprogramming}},
  url          = {{http://dx.doi.org/10.1038/s41586-018-0087-1}},
  doi          = {{10.1038/s41586-018-0087-1}},
  volume       = {{557}},
  year         = {{2018}},
}