New approaches for brain repair-from rescue to reprogramming
(2018) In Nature 557(7705). p.329-334- Abstract
The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/332a9d4a-a970-4159-885d-351731fae913
- author
- Barker, Roger A LU ; Götz, Magdalena and Parmar, Malin LU
- organization
- publishing date
- 2018-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Brain/cytology, Cellular Reprogramming/physiology, Fetal Tissue Transplantation, Humans, Nerve Regeneration/physiology, Neurodegenerative Diseases/pathology, Regenerative Medicine/methods, Stem Cell Transplantation
- in
- Nature
- volume
- 557
- issue
- 7705
- pages
- 329 - 334
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85047166027
- pmid:29769670
- ISSN
- 0028-0836
- DOI
- 10.1038/s41586-018-0087-1
- language
- English
- LU publication?
- yes
- id
- 332a9d4a-a970-4159-885d-351731fae913
- date added to LUP
- 2019-03-21 15:28:50
- date last changed
- 2024-09-17 16:17:57
@article{332a9d4a-a970-4159-885d-351731fae913, abstract = {{<p>The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.</p>}}, author = {{Barker, Roger A and Götz, Magdalena and Parmar, Malin}}, issn = {{0028-0836}}, keywords = {{Animals; Brain/cytology; Cellular Reprogramming/physiology; Fetal Tissue Transplantation; Humans; Nerve Regeneration/physiology; Neurodegenerative Diseases/pathology; Regenerative Medicine/methods; Stem Cell Transplantation}}, language = {{eng}}, number = {{7705}}, pages = {{329--334}}, publisher = {{Nature Publishing Group}}, series = {{Nature}}, title = {{New approaches for brain repair-from rescue to reprogramming}}, url = {{http://dx.doi.org/10.1038/s41586-018-0087-1}}, doi = {{10.1038/s41586-018-0087-1}}, volume = {{557}}, year = {{2018}}, }