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A population-based study of the outcome for patients with first relapse of Hodgkin's lymphoma

Amini, RM; Glimelius, B; Gustavsson, Anita LU ; Ekman, T; Erlanson, M; Haapaniemi, E and Enblad, G (2002) In European Journal of Haematology1987-01-01+01:00 68(4). p.225-232
Abstract
Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the... (More)
Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the National guidelines, the 5-yr Hodgkin-specific survival (HLS) was 85%, overall survival (OS) 73% and event-free survival (EFS) 62%, which is not inferior to survival in patients with primarily advanced stages. It was poorer in the 21 patients who initially had received RT only, even though they had been recommended for more extensive treatment. For patients initially treated with a full course (6-8 cycles) of CT the 5-yr HLS was 60%, OS 58% and EFS 22%. Bulky disease and age at diagnosis strongly affected survival in a multivariate analysis. Conclusions: Patients initially treated with RT who relapse have a favourable outcome, provided they have been treated according to the recommendations of the guidelines at the time of diagnosis. Initially bulky disease and, as a consequence, additional RT as part of the initial treatment negatively affect survival at relapse in patients initially treated with a full course of CT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
treatment, relapse, Hodgkin's lymphoma, prognostic factors
in
European Journal of Haematology1987-01-01+01:00
volume
68
issue
4
pages
225 - 232
publisher
Wiley-Blackwell
external identifiers
  • pmid:12071938
  • wos:000176473000006
  • scopus:0036288749
ISSN
1600-0609
DOI
10.1034/j.1600-0609.2002.01565.x
language
English
LU publication?
yes
id
3010afa6-1ab6-45ce-861c-756f13257d4e (old id 334548)
date added to LUP
2007-08-02 10:51:23
date last changed
2017-01-01 04:27:18
@article{3010afa6-1ab6-45ce-861c-756f13257d4e,
  abstract     = {Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the National guidelines, the 5-yr Hodgkin-specific survival (HLS) was 85%, overall survival (OS) 73% and event-free survival (EFS) 62%, which is not inferior to survival in patients with primarily advanced stages. It was poorer in the 21 patients who initially had received RT only, even though they had been recommended for more extensive treatment. For patients initially treated with a full course (6-8 cycles) of CT the 5-yr HLS was 60%, OS 58% and EFS 22%. Bulky disease and age at diagnosis strongly affected survival in a multivariate analysis. Conclusions: Patients initially treated with RT who relapse have a favourable outcome, provided they have been treated according to the recommendations of the guidelines at the time of diagnosis. Initially bulky disease and, as a consequence, additional RT as part of the initial treatment negatively affect survival at relapse in patients initially treated with a full course of CT.},
  author       = {Amini, RM and Glimelius, B and Gustavsson, Anita and Ekman, T and Erlanson, M and Haapaniemi, E and Enblad, G},
  issn         = {1600-0609},
  keyword      = {treatment,relapse,Hodgkin's lymphoma,prognostic factors},
  language     = {eng},
  number       = {4},
  pages        = {225--232},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology1987-01-01+01:00},
  title        = {A population-based study of the outcome for patients with first relapse of Hodgkin's lymphoma},
  url          = {http://dx.doi.org/10.1034/j.1600-0609.2002.01565.x},
  volume       = {68},
  year         = {2002},
}