A diabetes-predictive amino acid score and future cardiovascular disease.
(2013) In European Heart Journal 34(26). p.1982-1989- Abstract
- AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts development of CVD and its functional consequences.Methods and resultsWe performed a matched case-control study derived from the population-based Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC), all free of CVD. During 12 years of follow-up, 253 individuals developed CVD and were matched for age, sex, and Framingham risk score with 253 controls.... (More)
- AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts development of CVD and its functional consequences.Methods and resultsWe performed a matched case-control study derived from the population-based Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC), all free of CVD. During 12 years of follow-up, 253 individuals developed CVD and were matched for age, sex, and Framingham risk score with 253 controls. Amino acids were profiled in baseline plasma samples, using liquid chromatography-tandem mass spectrometry, and relationship to incident CVD was assessed using conditional logistic regression. We further examined whether the amino acid score also correlated with anatomical [intima-media thickness (IMT) and plaque formation] and functional (exercise-induced myocardial ischaemia) abnormalities. Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for incident CVD in subjects belonging to quartiles 2, 3, and 4 was 1.27 (0.72-2.22), 1.96 (1.07-3.60), and 2.20 (1.12-4.31) (P(trend) = 0.010), respectively, after multivariate adjustment. Increasing quartile of the DM-AA score was cross-sectionally related to carotid IMT (P(trend) = 0.037) and with the presence of at least one plaque larger than 10 mm(2) (P(trend) = 0.001). Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for inducible ischaemia in subjects belonging to quartiles 2, 3, and 4 was 3.31 (1.05-10.4), 4.24 (1.36-13.3), and 4.86 (1.47-16.1) (P(trend) = 0.011), respectively.ConclusionThis study identifies branched-chain and aromatic amino acids as novel markers of CVD development and as an early link between diabetes and CVD susceptibility. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347174
- author
- organization
-
- Department of Clinical Sciences, Malmö
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Epidemiology (research group)
- Internal Medicine - Epidemiology (research group)
- Cardiovascular Research - Hypertension (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Heart Journal
- volume
- 34
- issue
- 26
- pages
- 1982 - 1989
- publisher
- Oxford University Press
- external identifiers
-
- wos:000321831900011
- pmid:23242195
- scopus:84874649474
- pmid:23242195
- ISSN
- 1522-9645
- DOI
- 10.1093/eurheartj/ehs424
- project
- The use of Genomics and Proteomics for the Detection and Prevention of Cardiometabolic Disease
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Diabetes and cardiovascular disease - genetic epidemiology (013241590), Cardio-vascular Epidemiology (013241610), Internal Medicine Research Unit (013242520), Hypertension and Cardiovascular Disease (013242540)
- id
- 7338a42a-24fb-487c-976b-de00520c2753 (old id 3347174)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23242195?dopt=Abstract
- date added to LUP
- 2016-04-01 10:11:12
- date last changed
- 2024-01-06 09:48:46
@article{7338a42a-24fb-487c-976b-de00520c2753, abstract = {{AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts development of CVD and its functional consequences.Methods and resultsWe performed a matched case-control study derived from the population-based Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC), all free of CVD. During 12 years of follow-up, 253 individuals developed CVD and were matched for age, sex, and Framingham risk score with 253 controls. Amino acids were profiled in baseline plasma samples, using liquid chromatography-tandem mass spectrometry, and relationship to incident CVD was assessed using conditional logistic regression. We further examined whether the amino acid score also correlated with anatomical [intima-media thickness (IMT) and plaque formation] and functional (exercise-induced myocardial ischaemia) abnormalities. Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for incident CVD in subjects belonging to quartiles 2, 3, and 4 was 1.27 (0.72-2.22), 1.96 (1.07-3.60), and 2.20 (1.12-4.31) (P(trend) = 0.010), respectively, after multivariate adjustment. Increasing quartile of the DM-AA score was cross-sectionally related to carotid IMT (P(trend) = 0.037) and with the presence of at least one plaque larger than 10 mm(2) (P(trend) = 0.001). Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for inducible ischaemia in subjects belonging to quartiles 2, 3, and 4 was 3.31 (1.05-10.4), 4.24 (1.36-13.3), and 4.86 (1.47-16.1) (P(trend) = 0.011), respectively.ConclusionThis study identifies branched-chain and aromatic amino acids as novel markers of CVD development and as an early link between diabetes and CVD susceptibility.}}, author = {{Magnusson, Martin and Lewis, Gregory D and Ericson, Ulrika and Orho-Melander, Marju and Hedblad, Bo and Engström, Gunnar and Östling, Gerd and Clish, Clary and Wang, Thomas J and Gerszten, Robert E and Melander, Olle}}, issn = {{1522-9645}}, language = {{eng}}, number = {{26}}, pages = {{1982--1989}}, publisher = {{Oxford University Press}}, series = {{European Heart Journal}}, title = {{A diabetes-predictive amino acid score and future cardiovascular disease.}}, url = {{https://lup.lub.lu.se/search/files/1635311/3615326.pdf}}, doi = {{10.1093/eurheartj/ehs424}}, volume = {{34}}, year = {{2013}}, }