No diagnostic value of plasma clusterin in Alzheimer's disease.
Silajdzic, Edina LU ; Minthon, Lennart LU ; Björkqvist, Maria LU
and Hansson, Oskar
LU
(2012)
In PLoS ONE
7(11).
- Abstract
- There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin... (More)
- There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347672
- author
- Silajdzic, Edina
LU
; Minthon, Lennart
LU
; Björkqvist, Maria
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 7
- issue
- 11
- article number
- e50237
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000312601700046
- pmid:23209684
- scopus:84870359901
- pmid:23209684
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0050237
- language
- English
- LU publication?
- yes
- id
- 090a80e5-e4c3-45f3-8c0f-bfb4d5ab9a18 (old id 3347672)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23209684?dopt=Abstract
- date added to LUP
- 2016-04-01 13:54:56
- date last changed
- 2023-09-03 06:54:59
@article{090a80e5-e4c3-45f3-8c0f-bfb4d5ab9a18,
abstract = {{There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.}},
author = {{Silajdzic, Edina and Minthon, Lennart and Björkqvist, Maria and Hansson, Oskar}},
issn = {{1932-6203}},
language = {{eng}},
number = {{11}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{No diagnostic value of plasma clusterin in Alzheimer's disease.}},
url = {{https://lup.lub.lu.se/search/files/3662999/3596096.pdf}},
doi = {{10.1371/journal.pone.0050237}},
volume = {{7}},
year = {{2012}},
}