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No diagnostic value of plasma clusterin in Alzheimer's disease.

Silajdzic, Edina LU ; Minthon, Lennart LU ; Björkqvist, Maria LU and Hansson, Oskar LU (2012) In PLoS ONE 7(11).
Abstract
There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin... (More)
There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
7
issue
11
publisher
Public Library of Science
external identifiers
  • wos:000312601700046
  • pmid:23209684
  • scopus:84870359901
ISSN
1932-6203
DOI
10.1371/journal.pone.0050237
language
English
LU publication?
yes
id
090a80e5-e4c3-45f3-8c0f-bfb4d5ab9a18 (old id 3347672)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23209684?dopt=Abstract
date added to LUP
2013-01-02 11:37:11
date last changed
2017-11-05 04:03:40
@article{090a80e5-e4c3-45f3-8c0f-bfb4d5ab9a18,
  abstract     = {There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.},
  articleno    = {e50237},
  author       = {Silajdzic, Edina and Minthon, Lennart and Björkqvist, Maria and Hansson, Oskar},
  issn         = {1932-6203},
  language     = {eng},
  number       = {11},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {No diagnostic value of plasma clusterin in Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0050237},
  volume       = {7},
  year         = {2012},
}