Mechanical deformation of compressible chromatographic columns
(2002) In Biotechnology Progress 18(3). p.587-596- Abstract
- A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect... (More)
- A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/335579
- author
- Keener, RN ; Maneval, JE ; Östergren, Karin LU and Fernandez, EJ
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biotechnology Progress
- volume
- 18
- issue
- 3
- pages
- 587 - 596
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000176178300026
- scopus:0035988054
- ISSN
- 1520-6033
- DOI
- 10.1021/bp020051v
- language
- English
- LU publication?
- yes
- id
- 0408d985-a5bd-4958-9ba7-48bc48705a95 (old id 335579)
- date added to LUP
- 2016-04-01 15:58:44
- date last changed
- 2023-10-16 13:24:49
@article{0408d985-a5bd-4958-9ba7-48bc48705a95,
abstract = {{A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns.}},
author = {{Keener, RN and Maneval, JE and Östergren, Karin and Fernandez, EJ}},
issn = {{1520-6033}},
language = {{eng}},
number = {{3}},
pages = {{587--596}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Biotechnology Progress}},
title = {{Mechanical deformation of compressible chromatographic columns}},
url = {{http://dx.doi.org/10.1021/bp020051v}},
doi = {{10.1021/bp020051v}},
volume = {{18}},
year = {{2002}},
}