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Mechanical deformation of compressible chromatographic columns

Keener, RN; Maneval, JE; Östergren, Karin LU and Fernandez, EJ (2002) In Biotechnology Progress 18(3). p.587-596
Abstract
A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect... (More)
A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biotechnology Progress
volume
18
issue
3
pages
587 - 596
publisher
The American Chemical Society
external identifiers
  • wos:000176178300026
  • scopus:0035988054
ISSN
1520-6033
DOI
10.1021/bp020051v
language
English
LU publication?
yes
id
0408d985-a5bd-4958-9ba7-48bc48705a95 (old id 335579)
date added to LUP
2007-11-07 13:50:45
date last changed
2017-09-03 04:31:47
@article{0408d985-a5bd-4958-9ba7-48bc48705a95,
  abstract     = {A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns.},
  author       = {Keener, RN and Maneval, JE and Östergren, Karin and Fernandez, EJ},
  issn         = {1520-6033},
  language     = {eng},
  number       = {3},
  pages        = {587--596},
  publisher    = {The American Chemical Society},
  series       = {Biotechnology Progress},
  title        = {Mechanical deformation of compressible chromatographic columns},
  url          = {http://dx.doi.org/10.1021/bp020051v},
  volume       = {18},
  year         = {2002},
}