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Perinatal and Family Risk Factors for Hodgkin Lymphoma in Childhood Through Young Adulthood

Crump, Casey; Sundquist, Kristina LU ; Sieh, Weiva; Winkleby, Marilyn A. and Sundquist, Jan LU (2012) In American Journal of Epidemiology 176(12). p.1147-1158
Abstract
The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 19732008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood (ages 037 years). There were 943 Hodgkin lymphoma cases identified in 66.3 million person-years of follow-up. High fetal growth was associated with an increased risk of Hodgkin lymphoma after adjustment for gestational age at birth and other potential confounders (P-trend 0.005). Family history of Hodgkin lymphoma in a sibling... (More)
The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 19732008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood (ages 037 years). There were 943 Hodgkin lymphoma cases identified in 66.3 million person-years of follow-up. High fetal growth was associated with an increased risk of Hodgkin lymphoma after adjustment for gestational age at birth and other potential confounders (P-trend 0.005). Family history of Hodgkin lymphoma in a sibling or parent also was strongly associated with an increased risk, with adjusted hazard ratios 8.83 (95 confidence interval: 3.67, 21.30) and 7.19 (95 confidence interval: 3.58, 14.44), respectively. No association was found between gestational age at birth, birth order, twinning, parental age, or parental education and Hodgkin lymphoma. These findings did not vary by age at Hodgkin lymphoma diagnosis. Similar associations were found for nodular sclerosis and mixed cellularity subtypes. These findings suggest that perinatal factors including possible growth factor pathways may contribute to the risk of Hodgkin lymphoma in childhood through young adulthood. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
birth order, family, fetal development, gestational age, Hodgkin, disease, lymphoma, maternal age
in
American Journal of Epidemiology
volume
176
issue
12
pages
1147 - 1158
publisher
Oxford University Press
external identifiers
  • wos:000312634900011
  • scopus:84871232651
ISSN
0002-9262
DOI
10.1093/aje/kws212
language
English
LU publication?
yes
id
c6a4ee79-bd02-4b38-aeb8-4d218982ea3a (old id 3366163)
date added to LUP
2013-02-01 06:56:10
date last changed
2017-09-10 03:06:53
@article{c6a4ee79-bd02-4b38-aeb8-4d218982ea3a,
  abstract     = {The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 19732008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood (ages 037 years). There were 943 Hodgkin lymphoma cases identified in 66.3 million person-years of follow-up. High fetal growth was associated with an increased risk of Hodgkin lymphoma after adjustment for gestational age at birth and other potential confounders (P-trend 0.005). Family history of Hodgkin lymphoma in a sibling or parent also was strongly associated with an increased risk, with adjusted hazard ratios 8.83 (95 confidence interval: 3.67, 21.30) and 7.19 (95 confidence interval: 3.58, 14.44), respectively. No association was found between gestational age at birth, birth order, twinning, parental age, or parental education and Hodgkin lymphoma. These findings did not vary by age at Hodgkin lymphoma diagnosis. Similar associations were found for nodular sclerosis and mixed cellularity subtypes. These findings suggest that perinatal factors including possible growth factor pathways may contribute to the risk of Hodgkin lymphoma in childhood through young adulthood.},
  author       = {Crump, Casey and Sundquist, Kristina and Sieh, Weiva and Winkleby, Marilyn A. and Sundquist, Jan},
  issn         = {0002-9262},
  keyword      = {birth order,family,fetal development,gestational age,Hodgkin,disease,lymphoma,maternal age},
  language     = {eng},
  number       = {12},
  pages        = {1147--1158},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Perinatal and Family Risk Factors for Hodgkin Lymphoma in Childhood Through Young Adulthood},
  url          = {http://dx.doi.org/10.1093/aje/kws212},
  volume       = {176},
  year         = {2012},
}