Advanced

Chronic hyperbaric exposure activates proinflammatory mediators in humans

Ersson, Anders LU ; Walles, Maria LU ; Ohlsson, K and Ekholm, A (2002) In Journal of Applied Physiology 92(6). p.2375-2380
Abstract
Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not... (More)
Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
decompression, diving, inflammatory activation
in
Journal of Applied Physiology
volume
92
issue
6
pages
2375 - 2380
publisher
American Physiological Society
external identifiers
  • pmid:12015350
  • wos:000175739200020
  • scopus:0036082172
ISSN
1522-1601
DOI
10.1152/japplphysiol.00705.2001
language
English
LU publication?
yes
id
4dce52fd-babb-40ae-b02d-557ea3285744 (old id 337183)
date added to LUP
2007-08-17 11:21:26
date last changed
2017-03-05 03:38:51
@article{4dce52fd-babb-40ae-b02d-557ea3285744,
  abstract     = {Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system.},
  author       = {Ersson, Anders and Walles, Maria and Ohlsson, K and Ekholm, A},
  issn         = {1522-1601},
  keyword      = {decompression,diving,inflammatory activation},
  language     = {eng},
  number       = {6},
  pages        = {2375--2380},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Chronic hyperbaric exposure activates proinflammatory mediators in humans},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00705.2001},
  volume       = {92},
  year         = {2002},
}