Advanced

Iduronic Acid in Chondroitin/Dermatan Sulfate: Biosynthesis and Biological Function

Malmström, Anders LU ; Bartolini, Barbara LU ; Thelin, Martin LU ; Pacheco, Benny LU and Maccarana, Marco LU (2012) In Journal of Histochemistry and Cytochemistry 60(12). p.916-925
Abstract
The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is enriched by the presence of iduronic acid. DS-epimerases 1 and 2 (DS-epi1 and 2), in conjunction with DS-4-O-sulfotransferase 1, are the enzymes responsible for iduronic acid biosynthesis and will be the major focus of this review. CS/DS proteoglycans (CS/DS-PGs) are ubiquitously found in connective tissues, basement membranes, and cell surfaces or are stored intracellularly. Such wide distribution reflects the variety of biological roles in which they are involved, from extracellular matrix organization to regulation of processes such as proliferation, migration, adhesion, and differentiation. They play roles in inflammation, angiogenesis, coagulation,... (More)
The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is enriched by the presence of iduronic acid. DS-epimerases 1 and 2 (DS-epi1 and 2), in conjunction with DS-4-O-sulfotransferase 1, are the enzymes responsible for iduronic acid biosynthesis and will be the major focus of this review. CS/DS proteoglycans (CS/DS-PGs) are ubiquitously found in connective tissues, basement membranes, and cell surfaces or are stored intracellularly. Such wide distribution reflects the variety of biological roles in which they are involved, from extracellular matrix organization to regulation of processes such as proliferation, migration, adhesion, and differentiation. They play roles in inflammation, angiogenesis, coagulation, immunity, and wound healing. Such versatility is achieved thanks to their variable composition, both in terms of protein core and the fine structure of the CS/DS chains. Excellent reviews have been published on the collective and individual functions of each CS/DS-PG. This short review presents the biosynthesis and functions of iduronic acid-containing structures, also as revealed by the analysis of the DS-epi1- and 2-deficient mouse models. (J Histochem Cytochem 60: 916-925, 2012) (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chondroitin sulfate, CS/DS proteoglycans, dermatan sulfate, dermatan, sulfate epimerase 1 and 2, dermatan sulfate 4-O-sulfotransferase 1
in
Journal of Histochemistry and Cytochemistry
volume
60
issue
12
pages
916 - 925
publisher
Histochemical Society
external identifiers
  • wos:000311683500004
  • scopus:84873043031
ISSN
0022-1554
DOI
10.1369/0022155412459857
language
English
LU publication?
yes
id
108c8aca-03f0-4c3b-b46f-0d176f8d534e (old id 3372738)
date added to LUP
2013-02-01 07:00:42
date last changed
2017-08-27 04:38:11
@article{108c8aca-03f0-4c3b-b46f-0d176f8d534e,
  abstract     = {The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is enriched by the presence of iduronic acid. DS-epimerases 1 and 2 (DS-epi1 and 2), in conjunction with DS-4-O-sulfotransferase 1, are the enzymes responsible for iduronic acid biosynthesis and will be the major focus of this review. CS/DS proteoglycans (CS/DS-PGs) are ubiquitously found in connective tissues, basement membranes, and cell surfaces or are stored intracellularly. Such wide distribution reflects the variety of biological roles in which they are involved, from extracellular matrix organization to regulation of processes such as proliferation, migration, adhesion, and differentiation. They play roles in inflammation, angiogenesis, coagulation, immunity, and wound healing. Such versatility is achieved thanks to their variable composition, both in terms of protein core and the fine structure of the CS/DS chains. Excellent reviews have been published on the collective and individual functions of each CS/DS-PG. This short review presents the biosynthesis and functions of iduronic acid-containing structures, also as revealed by the analysis of the DS-epi1- and 2-deficient mouse models. (J Histochem Cytochem 60: 916-925, 2012)},
  author       = {Malmström, Anders and Bartolini, Barbara and Thelin, Martin and Pacheco, Benny and Maccarana, Marco},
  issn         = {0022-1554},
  keyword      = {chondroitin sulfate,CS/DS proteoglycans,dermatan sulfate,dermatan,sulfate epimerase 1 and 2,dermatan sulfate 4-O-sulfotransferase 1},
  language     = {eng},
  number       = {12},
  pages        = {916--925},
  publisher    = {Histochemical Society},
  series       = {Journal of Histochemistry and Cytochemistry},
  title        = {Iduronic Acid in Chondroitin/Dermatan Sulfate: Biosynthesis and Biological Function},
  url          = {http://dx.doi.org/10.1369/0022155412459857},
  volume       = {60},
  year         = {2012},
}