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Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers : Results from a population-based proteomics study

Borné, Yan LU ; Fagerberg, Björn ; Sallsten, Gerd ; Hedblad, Bo LU ; Persson, Margaretha LU orcid ; Melander, Olle LU orcid ; Nilsson, Jan LU ; Orho-Melander, Marju LU ; Barregard, Lars and Engström, Gunnar LU (2019) In Clinical Proteomics 16(1).
Abstract

Background: Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods: B-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmö Diet and Cancer study. The primary analysis was performed in never smokers (n = 1725). Multiple linear regression was used with adjustments for age and sex, and correction for multiple comparisons using the false discovery rate method. Proteins significantly associated with B-Cd were replicated in long-term former smokers (n = 782). Significant... (More)

Background: Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods: B-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmö Diet and Cancer study. The primary analysis was performed in never smokers (n = 1725). Multiple linear regression was used with adjustments for age and sex, and correction for multiple comparisons using the false discovery rate method. Proteins significantly associated with B-Cd were replicated in long-term former smokers (n = 782). Significant proteins were then studied in relation to incidence of CVD (i.e., coronary events or ischemic stroke) in never smokers. Results: Fifteen proteins were associated with B-Cd in never smokers. Eight of them were replicated in long-term former smokers. Kidney injury molecule-1, fibroblast growth factor-23 (FGF23), tumor necrosis factor receptor-2, matrix metalloproteinase-12, cathepsin L1, urokinase plasminogen activator receptor, C-C motif chemokine-3 (CCL3), and chemokine (C-X3-C motif) ligand-1 were associated with B-Cd both in never smokers and long-term former smokers. Except for CCL3 and FGF23, these proteins were also significantly associated with incidence of CVD. Conclusions: B-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cadmium, Cohort study, CVD, Non-smokers, Proteomics study
in
Clinical Proteomics
volume
16
issue
1
article number
21
publisher
Humana Press
external identifiers
  • pmid:31114450
  • scopus:85066051365
ISSN
1542-6416
DOI
10.1186/s12014-019-9231-7
language
English
LU publication?
yes
id
33821a7d-622d-4b80-a6f7-c78bd6336ee1
date added to LUP
2019-06-11 13:42:02
date last changed
2024-03-14 02:48:54
@article{33821a7d-622d-4b80-a6f7-c78bd6336ee1,
  abstract     = {{<p>Background: Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods: B-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmö Diet and Cancer study. The primary analysis was performed in never smokers (n = 1725). Multiple linear regression was used with adjustments for age and sex, and correction for multiple comparisons using the false discovery rate method. Proteins significantly associated with B-Cd were replicated in long-term former smokers (n = 782). Significant proteins were then studied in relation to incidence of CVD (i.e., coronary events or ischemic stroke) in never smokers. Results: Fifteen proteins were associated with B-Cd in never smokers. Eight of them were replicated in long-term former smokers. Kidney injury molecule-1, fibroblast growth factor-23 (FGF23), tumor necrosis factor receptor-2, matrix metalloproteinase-12, cathepsin L1, urokinase plasminogen activator receptor, C-C motif chemokine-3 (CCL3), and chemokine (C-X3-C motif) ligand-1 were associated with B-Cd both in never smokers and long-term former smokers. Except for CCL3 and FGF23, these proteins were also significantly associated with incidence of CVD. Conclusions: B-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.</p>}},
  author       = {{Borné, Yan and Fagerberg, Björn and Sallsten, Gerd and Hedblad, Bo and Persson, Margaretha and Melander, Olle and Nilsson, Jan and Orho-Melander, Marju and Barregard, Lars and Engström, Gunnar}},
  issn         = {{1542-6416}},
  keywords     = {{Cadmium; Cohort study; CVD; Non-smokers; Proteomics study}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  publisher    = {{Humana Press}},
  series       = {{Clinical Proteomics}},
  title        = {{Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers : Results from a population-based proteomics study}},
  url          = {{http://dx.doi.org/10.1186/s12014-019-9231-7}},
  doi          = {{10.1186/s12014-019-9231-7}},
  volume       = {{16}},
  year         = {{2019}},
}