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5 ' flanking variants of resistin are associated with obesity

Engert, JC; Vohl, MC; Williams, SM; Lepage, P; Loredo-Osti, JC; Faith, J; Dore, C; Renaud, Y; Burtt, NP and Villeneuve, A, et al. (2002) In Diabetes 51(5). p.1629-1634
Abstract
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated... (More)
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples. (Less)
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type
Contribution to journal
publication status
published
subject
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Diabetes
volume
51
issue
5
pages
1629 - 1634
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000175492400042
  • pmid:11978666
  • scopus:0036020829
ISSN
1939-327X
DOI
10.2337/diabetes.51.5.1629
language
English
LU publication?
yes
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1be98e7d-01d0-40eb-870e-793f2bfda379 (old id 338383)
date added to LUP
2007-08-17 08:47:22
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2017-12-10 04:28:11
@article{1be98e7d-01d0-40eb-870e-793f2bfda379,
  abstract     = {Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.},
  author       = {Engert, JC and Vohl, MC and Williams, SM and Lepage, P and Loredo-Osti, JC and Faith, J and Dore, C and Renaud, Y and Burtt, NP and Villeneuve, A and Hirschhorn, JN and Altshuler, D and Groop, Leif and Despres, JP and Gaudet, D and Hudson, TJ},
  issn         = {1939-327X},
  language     = {eng},
  number       = {5},
  pages        = {1629--1634},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {5 ' flanking variants of resistin are associated with obesity},
  url          = {http://dx.doi.org/10.2337/diabetes.51.5.1629},
  volume       = {51},
  year         = {2002},
}