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The rate and pattern of organ damage in late onset systemic lupus erythematosus

Maddison, P; Farewell, V; Isenberg, D; Aranow, C; Bae, SC; Barr, S; Buyon, J; Fortin, P; Ginzler, E and Gladman, D, et al. (2002) In Journal of Rheumatology 29(5). p.913-917
Abstract
Objective. To compare the extent and type of damage in patients with late onset and earlier onset Systemic lupus erythematosus (SLE) using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Methods. A total of 86 SLE patients with disease onset after the age of 54 years were matched for center, sex, and ethnic origin with 155 SLE patients with disease onset before the age of 40 years. SDI scores were obtained at one year and 5 years after the diagnosis of SLE. Analysis was based on conditional logistic regression. Results. SDI scores were higher in the late onset group than in younger patients at both one [mean 0.7 (range 0-3) vs 0.3 (range 0-3). p < 0.001] and 5 years [mean 1.6... (More)
Objective. To compare the extent and type of damage in patients with late onset and earlier onset Systemic lupus erythematosus (SLE) using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Methods. A total of 86 SLE patients with disease onset after the age of 54 years were matched for center, sex, and ethnic origin with 155 SLE patients with disease onset before the age of 40 years. SDI scores were obtained at one year and 5 years after the diagnosis of SLE. Analysis was based on conditional logistic regression. Results. SDI scores were higher in the late onset group than in younger patients at both one [mean 0.7 (range 0-3) vs 0.3 (range 0-3). p < 0.001] and 5 years [mean 1.6 (range 0-8) vs 0.9 (range 0-7); p < 0.001] after diagnosis. There was also a difference in the pattern of organ damage. While damage to the skin, kidneys, and central nervous system occurred with similar frequency, late onset disease was characterized by significantly more cardiovascular (OR 14.13, p < 0.001). ocular (OR 9.38, p 0.001), and musculoskeletal (OR 2.68, p = 0.016) damage and malignancy (OR 7.04, 3 = 0.046). Conclusion. The occurrence of organ damage assessed by the SDI is greater in patients with late onset SLE than in younger patients and, by this criterion, lupus cannot be judged to be more benign in this age group. Also, the pattern of damage is different, but whether this reflects age per se or the effect of the disease in the elderly remains to be established. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
systemic lupus erythematosus, late onset lupus, SLICC/ACR damage index
in
Journal of Rheumatology
volume
29
issue
5
pages
913 - 917
publisher
J Rheumatol Publ Co
external identifiers
  • pmid:12022349
  • wos:000175430100009
  • scopus:0036256810
ISSN
0315-162X
language
English
LU publication?
yes
id
97fd159e-812b-4393-86e6-cada2b5eff1e (old id 338550)
date added to LUP
2007-11-16 13:21:17
date last changed
2017-09-24 03:27:36
@article{97fd159e-812b-4393-86e6-cada2b5eff1e,
  abstract     = {Objective. To compare the extent and type of damage in patients with late onset and earlier onset Systemic lupus erythematosus (SLE) using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Methods. A total of 86 SLE patients with disease onset after the age of 54 years were matched for center, sex, and ethnic origin with 155 SLE patients with disease onset before the age of 40 years. SDI scores were obtained at one year and 5 years after the diagnosis of SLE. Analysis was based on conditional logistic regression. Results. SDI scores were higher in the late onset group than in younger patients at both one [mean 0.7 (range 0-3) vs 0.3 (range 0-3). p &lt; 0.001] and 5 years [mean 1.6 (range 0-8) vs 0.9 (range 0-7); p &lt; 0.001] after diagnosis. There was also a difference in the pattern of organ damage. While damage to the skin, kidneys, and central nervous system occurred with similar frequency, late onset disease was characterized by significantly more cardiovascular (OR 14.13, p &lt; 0.001). ocular (OR 9.38, p 0.001), and musculoskeletal (OR 2.68, p = 0.016) damage and malignancy (OR 7.04, 3 = 0.046). Conclusion. The occurrence of organ damage assessed by the SDI is greater in patients with late onset SLE than in younger patients and, by this criterion, lupus cannot be judged to be more benign in this age group. Also, the pattern of damage is different, but whether this reflects age per se or the effect of the disease in the elderly remains to be established.},
  author       = {Maddison, P and Farewell, V and Isenberg, D and Aranow, C and Bae, SC and Barr, S and Buyon, J and Fortin, P and Ginzler, E and Gladman, D and Hanly, J and Manzi, S and Nived, Ola and Petri, M and Ramsey-Goldman, R and Sturfelt, Gunnar},
  issn         = {0315-162X},
  keyword      = {systemic lupus erythematosus,late onset lupus,SLICC/ACR damage index},
  language     = {eng},
  number       = {5},
  pages        = {913--917},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {The rate and pattern of organ damage in late onset systemic lupus erythematosus},
  volume       = {29},
  year         = {2002},
}