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Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Verotta, L ; Appendino, G ; Belloro, E ; Bianchi, F ; Sterner, Olov LU ; Lovati, M and Bombardelli, E (2002) In Journal of Natural Products 65(4). p.433-438
Abstract
Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
65
issue
4
pages
433 - 438
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:11975475
  • wos:000175327700001
  • scopus:0036235522
ISSN
0163-3864
DOI
10.1021/np0105681
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
ffca9568-0af6-46e6-b71e-a7ec6b71744c (old id 339532)
date added to LUP
2016-04-01 16:34:47
date last changed
2020-12-08 03:13:02
@article{ffca9568-0af6-46e6-b71e-a7ec6b71744c,
  abstract     = {Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.},
  author       = {Verotta, L and Appendino, G and Belloro, E and Bianchi, F and Sterner, Olov and Lovati, M and Bombardelli, E},
  issn         = {0163-3864},
  language     = {eng},
  number       = {4},
  pages        = {433--438},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Journal of Natural Products},
  title        = {Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety},
  url          = {http://dx.doi.org/10.1021/np0105681},
  doi          = {10.1021/np0105681},
  volume       = {65},
  year         = {2002},
}