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Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation

Wagers, S; Lundblad, Lennart LU ; Moriya, HT; Bates, JHT and Irvin, CG (2002) In Journal of Applied Physiology 92(5). p.1802-1807
Abstract
Respiratory system resistance (R) and elastance (E) are commonly estimated by fitting the linear equation of motion P = EV + R(V) over dot + P-0 (Eq. 1) to measurements of respiratory pressure (P), lung volume (V), and flow (V). However, the respiratory system is unlikely to behave linearly under many circumstances. We determined the importance of respiratory system nonlinearities in two groups of mechanically ventilated Balb/c mice [controls and mice with allergically inflamed airways (ova/ova)], by,g the impact of the addition of nonlinear terms (E2V2 assessing and R-2(V) over dot (V) over dot) on the goodness of model fit seen with Eq. 1. Significant improvement in fit (51.85 +/- 4.19%) was on seen in the ova/ova mice during... (More)
Respiratory system resistance (R) and elastance (E) are commonly estimated by fitting the linear equation of motion P = EV + R(V) over dot + P-0 (Eq. 1) to measurements of respiratory pressure (P), lung volume (V), and flow (V). However, the respiratory system is unlikely to behave linearly under many circumstances. We determined the importance of respiratory system nonlinearities in two groups of mechanically ventilated Balb/c mice [controls and mice with allergically inflamed airways (ova/ova)], by,g the impact of the addition of nonlinear terms (E2V2 assessing and R-2(V) over dot (V) over dot) on the goodness of model fit seen with Eq. 1. Significant improvement in fit (51.85 +/- 4.19%) was on seen in the ova/ova mice during bronchoconstriction when the E2V2 alone was added. An improvement was also observed with addition of the E2V2 term in mice with both low and high lung volumes ventilated at baseline, suggesting a volume-dependent nonlinearity of E. We speculate that airway closure in the constricted ova/ova mice accentuated the volume-dependent nonlinearity by decreasing lung volume and overdistending the remaining lung. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pulmonary, mechanics, elastance, resistance, hysteresis, airway closure, asthma
in
Journal of Applied Physiology
volume
92
issue
5
pages
1802 - 1807
publisher
American Physiological Society
external identifiers
  • wos:000175184900005
  • pmid:11960927
  • scopus:0036088454
ISSN
1522-1601
DOI
10.1152/japplphysiol.00883.2001
language
English
LU publication?
yes
id
8267c9cd-5501-4e29-a879-6a9ed6712114 (old id 339959)
date added to LUP
2007-11-19 14:37:54
date last changed
2017-09-10 03:41:40
@article{8267c9cd-5501-4e29-a879-6a9ed6712114,
  abstract     = {Respiratory system resistance (R) and elastance (E) are commonly estimated by fitting the linear equation of motion P = EV + R(V) over dot + P-0 (Eq. 1) to measurements of respiratory pressure (P), lung volume (V), and flow (V). However, the respiratory system is unlikely to behave linearly under many circumstances. We determined the importance of respiratory system nonlinearities in two groups of mechanically ventilated Balb/c mice [controls and mice with allergically inflamed airways (ova/ova)], by,g the impact of the addition of nonlinear terms (E2V2 assessing and R-2(V) over dot (V) over dot) on the goodness of model fit seen with Eq. 1. Significant improvement in fit (51.85 +/- 4.19%) was on seen in the ova/ova mice during bronchoconstriction when the E2V2 alone was added. An improvement was also observed with addition of the E2V2 term in mice with both low and high lung volumes ventilated at baseline, suggesting a volume-dependent nonlinearity of E. We speculate that airway closure in the constricted ova/ova mice accentuated the volume-dependent nonlinearity by decreasing lung volume and overdistending the remaining lung.},
  author       = {Wagers, S and Lundblad, Lennart and Moriya, HT and Bates, JHT and Irvin, CG},
  issn         = {1522-1601},
  keyword      = {pulmonary,mechanics,elastance,resistance,hysteresis,airway closure,asthma},
  language     = {eng},
  number       = {5},
  pages        = {1802--1807},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00883.2001},
  volume       = {92},
  year         = {2002},
}