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Inertia induced breakdown of acoustic sorting efficiency at high flow rates

Undvall, Eva LU ; Garofalo, Fabio LU ; Procopio, Giuseppe ; Lenshof, Andreas LU ; Laurell, Thomas LU and Baasch, Thierry LU (2021) 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 p.895-896
Abstract

We investigated the impact of inertial forces on acoustic sorting at high sample throughputs. Above a critical flow rate, we observed an unexpected inertia induced breakdown of the sorting efficiency that is not due to the wall induced lift force and was not previously described in the literature. We analyzed the effect experimentally and theoretically, providing an explanation to the phenomena, and suggest conditions to maximize the sample throughput, while keeping the sorting efficiency intact. The observed phenomena is generic to all separation techniques that rely on field based (electrical, magnetic, acoustic) forces acting on cells/particles.

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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustic particle manipulation, Fluid mechanics, High throughput, Inertia, Microfluidic sorting
host publication
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
conference location
Palm Springs, Virtual, United States
conference dates
2021-10-10 - 2021-10-14
external identifiers
  • scopus:85136941020
ISBN
9781733419031
language
English
LU publication?
yes
id
339a1dbc-7b2b-48eb-8bb8-1d3ec1ef2435
date added to LUP
2022-11-08 11:37:08
date last changed
2023-10-23 06:29:03
@inproceedings{339a1dbc-7b2b-48eb-8bb8-1d3ec1ef2435,
  abstract     = {{<p>We investigated the impact of inertial forces on acoustic sorting at high sample throughputs. Above a critical flow rate, we observed an unexpected inertia induced breakdown of the sorting efficiency that is not due to the wall induced lift force and was not previously described in the literature. We analyzed the effect experimentally and theoretically, providing an explanation to the phenomena, and suggest conditions to maximize the sample throughput, while keeping the sorting efficiency intact. The observed phenomena is generic to all separation techniques that rely on field based (electrical, magnetic, acoustic) forces acting on cells/particles.</p>}},
  author       = {{Undvall, Eva and Garofalo, Fabio and Procopio, Giuseppe and Lenshof, Andreas and Laurell, Thomas and Baasch, Thierry}},
  booktitle    = {{MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences}},
  isbn         = {{9781733419031}},
  keywords     = {{Acoustic particle manipulation; Fluid mechanics; High throughput; Inertia; Microfluidic sorting}},
  language     = {{eng}},
  pages        = {{895--896}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  title        = {{Inertia induced breakdown of acoustic sorting efficiency at high flow rates}},
  year         = {{2021}},
}