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Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

Mattsson, Niklas LU orcid ; Insel, Philip S. LU ; Palmqvist, Sebastian LU orcid ; Portelius, Erik ; Zetterberg, Henrik LU ; Weiner, Michael ; Blennow, Kaj LU and Hansson, Oskar LU orcid (2016) In EMBO Molecular Medicine 8(10). p.1184-1196
Abstract

Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). T-tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β-amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain... (More)

Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). T-tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β-amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T-tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T-tau and Ng reflect Aβ-dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's, biomarker, CSF, neurodegeneration
in
EMBO Molecular Medicine
volume
8
issue
10
pages
13 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84989947774
  • pmid:27534871
  • wos:000387111700008
ISSN
1757-4676
DOI
10.15252/emmm.201606540
language
English
LU publication?
yes
id
33c2bfe2-ecfb-48ca-a318-ea8427b39a9b
date added to LUP
2016-10-21 12:28:59
date last changed
2025-01-12 13:37:03
@article{33c2bfe2-ecfb-48ca-a318-ea8427b39a9b,
  abstract     = {{<p>Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). T-tau and Ng were highly correlated (ρ = 0.79, P &lt; 0.001) and strongly associated with β-amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T-tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T-tau and Ng reflect Aβ-dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.</p>}},
  author       = {{Mattsson, Niklas and Insel, Philip S. and Palmqvist, Sebastian and Portelius, Erik and Zetterberg, Henrik and Weiner, Michael and Blennow, Kaj and Hansson, Oskar}},
  issn         = {{1757-4676}},
  keywords     = {{Alzheimer's; biomarker; CSF; neurodegeneration}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{1184--1196}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{EMBO Molecular Medicine}},
  title        = {{Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.15252/emmm.201606540}},
  doi          = {{10.15252/emmm.201606540}},
  volume       = {{8}},
  year         = {{2016}},
}