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Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease

Ewers, Michael; Schmitz, Susanne; Hansson, Oskar LU ; Walsh, Cathal; Fitzpatrick, Annette; Bennett, David; Minthon, Lennart LU ; Trojanowski, John Q.; Shaw, Leslie M. and Faluyi, Yetunde O., et al. (2012) In Neurobiology of Aging 33(8). p.1599-1608
Abstract
Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A beta(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was... (More)
Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A beta(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was significantly lower in the CSF+ when compared with the CSF- group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. Published by Elsevier Inc. (Less)
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publication status
published
subject
keywords
Alzheimer's disease, Body mass index, Cerebrospinal fluid, Tau protein, A beta(1-42)
in
Neurobiology of Aging
volume
33
issue
8
pages
1599 - 1608
publisher
Elsevier
external identifiers
  • wos:000306070800010
  • scopus:84861865381
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2011.05.005
language
English
LU publication?
yes
id
8a7d8a70-0fdc-4dfb-badb-aa19f2caa5b0 (old id 3400357)
date added to LUP
2013-02-01 07:04:38
date last changed
2017-11-05 03:11:08
@article{8a7d8a70-0fdc-4dfb-badb-aa19f2caa5b0,
  abstract     = {Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A beta(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was significantly lower in the CSF+ when compared with the CSF- group (F = 27.7, df = 746, p &lt; 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. Published by Elsevier Inc.},
  author       = {Ewers, Michael and Schmitz, Susanne and Hansson, Oskar and Walsh, Cathal and Fitzpatrick, Annette and Bennett, David and Minthon, Lennart and Trojanowski, John Q. and Shaw, Leslie M. and Faluyi, Yetunde O. and Vellas, Bruno and Dubois, Bruno and Blennow, Kaj and Buerger, Katharina and Teipel, Stefan J. and Weiner, Michael and Hampel, Harald},
  issn         = {1558-1497},
  keyword      = {Alzheimer's disease,Body mass index,Cerebrospinal fluid,Tau protein,A beta(1-42)},
  language     = {eng},
  number       = {8},
  pages        = {1599--1608},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2011.05.005},
  volume       = {33},
  year         = {2012},
}