CD-Sens Can Be a Reliable and Easy-to-Use Complement in the Diagnosis of Allergic Rhinitis
(2013) In International Archives of Allergy and Immunology 161(1). p.87-90- Abstract
- Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the... (More)
- Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification. Conclusion: CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects. Copyright (C) 2012 S. Karger AG, Basel (Less)
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https://lup.lub.lu.se/record/3400754
- author
- Nopp, A. ; Cardell, Lars-Olaf LU and Johansson, S. G. O.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Allergic rhinitis, Basophils, Flow cytometry, Nasal, allergen challenge, Peak nasal inspiratory flow
- in
- International Archives of Allergy and Immunology
- volume
- 161
- issue
- 1
- pages
- 87 - 90
- publisher
- Karger
- external identifiers
-
- wos:000312588300010
- scopus:84871243474
- pmid:23257907
- ISSN
- 1423-0097
- DOI
- 10.1159/000345133
- language
- English
- LU publication?
- yes
- id
- 22329837-5409-40c6-af2d-b336c7c7c8f6 (old id 3400754)
- date added to LUP
- 2016-04-01 10:45:45
- date last changed
- 2022-04-28 01:12:16
@article{22329837-5409-40c6-af2d-b336c7c7c8f6,
abstract = {{Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification. Conclusion: CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects. Copyright (C) 2012 S. Karger AG, Basel}},
author = {{Nopp, A. and Cardell, Lars-Olaf and Johansson, S. G. O.}},
issn = {{1423-0097}},
keywords = {{Allergic rhinitis; Basophils; Flow cytometry; Nasal; allergen challenge; Peak nasal inspiratory flow}},
language = {{eng}},
number = {{1}},
pages = {{87--90}},
publisher = {{Karger}},
series = {{International Archives of Allergy and Immunology}},
title = {{CD-Sens Can Be a Reliable and Easy-to-Use Complement in the Diagnosis of Allergic Rhinitis}},
url = {{http://dx.doi.org/10.1159/000345133}},
doi = {{10.1159/000345133}},
volume = {{161}},
year = {{2013}},
}