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CD-Sens Can Be a Reliable and Easy-to-Use Complement in the Diagnosis of Allergic Rhinitis

Nopp, A. ; Cardell, Lars-Olaf LU and Johansson, S. G. O. (2013) In International Archives of Allergy and Immunology 161(1). p.87-90
Abstract
Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the... (More)
Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification. Conclusion: CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects. Copyright (C) 2012 S. Karger AG, Basel (Less)
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author
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organization
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Contribution to journal
publication status
published
subject
keywords
Allergic rhinitis, Basophils, Flow cytometry, Nasal, allergen challenge, Peak nasal inspiratory flow
in
International Archives of Allergy and Immunology
volume
161
issue
1
pages
87 - 90
publisher
Karger
external identifiers
  • wos:000312588300010
  • scopus:84871243474
  • pmid:23257907
ISSN
1423-0097
DOI
10.1159/000345133
language
English
LU publication?
yes
id
22329837-5409-40c6-af2d-b336c7c7c8f6 (old id 3400754)
date added to LUP
2016-04-01 10:45:45
date last changed
2020-06-03 01:31:31
@article{22329837-5409-40c6-af2d-b336c7c7c8f6,
  abstract     = {Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score >= 2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. Results: CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification. Conclusion: CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects. Copyright (C) 2012 S. Karger AG, Basel},
  author       = {Nopp, A. and Cardell, Lars-Olaf and Johansson, S. G. O.},
  issn         = {1423-0097},
  language     = {eng},
  number       = {1},
  pages        = {87--90},
  publisher    = {Karger},
  series       = {International Archives of Allergy and Immunology},
  title        = {CD-Sens Can Be a Reliable and Easy-to-Use Complement in the Diagnosis of Allergic Rhinitis},
  url          = {http://dx.doi.org/10.1159/000345133},
  doi          = {10.1159/000345133},
  volume       = {161},
  year         = {2013},
}