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Enhanced insulin absorption in the rabbit airways and lung by sodium dioctyl sulfosuccinate

Dahlback, M; Eirefelt, S; Backstrom, K; Larsson, P; Almér, Lars-Olof LU ; Wollmer, Per LU and Jonson, Björn LU (2002) In Journal of Aerosol Medicine 15(1). p.27-36
Abstract
The objective of this investigation was to study regional absorption of inhaled insulin together with an enhancer (sodium di-octyl-sulfosuccinate [DOSS]) in the rabbit airways and lung. Insulin was administered with or without DOSS by aerosol inhalation, intratracheal infusion, intranasally, sublingually, and without DOSS intravenously. Blood glucose and plasma levels of insulin were measured during 100 min from the start of administration. Inhalation of insulin (3 U) with 0.25% or 1% DOSS decreased average blood glucose levels significantly more than inhalation of insulin (3 U) without DOSS. Intratracheal administration of 1.5 U of insulin with 0.25% DOSS in 0.3 mL of vehicle decreased the average blood glucose level significantly... (More)
The objective of this investigation was to study regional absorption of inhaled insulin together with an enhancer (sodium di-octyl-sulfosuccinate [DOSS]) in the rabbit airways and lung. Insulin was administered with or without DOSS by aerosol inhalation, intratracheal infusion, intranasally, sublingually, and without DOSS intravenously. Blood glucose and plasma levels of insulin were measured during 100 min from the start of administration. Inhalation of insulin (3 U) with 0.25% or 1% DOSS decreased average blood glucose levels significantly more than inhalation of insulin (3 U) without DOSS. Intratracheal administration of 1.5 U of insulin with 0.25% DOSS in 0.3 mL of vehicle decreased the average blood glucose level significantly compared with intratracheal administration of 1.5 U of insulin and no DOSS in 0.3 mL of vehicle and compared with 1.5 U of insulin with 0.25% DOSS in 0.15 mL of vehicle. Intravenous insulin (1.5 U) and inhaled (1.5 U) insulin in 0.25% DOSS decreased average blood glucose levels significantly compared with intratracheal (0.15 mL), intranasal, and sublingual administration of 1.5 U of insulin with 0.25% DOSS. The bioavailability of inhaled insulin (1.5 U) with 0.25% DOSS was estimated to be 16% in comparison with 7% for intratracheally (0.15 mL), 1% intranasally, and 0.8% sublingually administered insulin (1.5 U with 0.25% DOSS), respectively. Inhaled insulin together with the absorption enhancer DOSS decreased the blood glucose level more effectively than insulin given intratracheally, intranasally, or sublingually. The effect on blood glucose reflected the difference in plasma insulin concentration for the different routes of administration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung, insulin, enhancer, DOSS, airways, absorption, aerosol, rabbit
in
Journal of Aerosol Medicine
volume
15
issue
1
pages
27 - 36
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000174998700004
  • scopus:0036231092
ISSN
0894-2684
DOI
10.1089/08942680252908557
language
English
LU publication?
yes
id
31195177-15b2-451e-9b95-245a335fb95c (old id 340307)
date added to LUP
2007-08-15 14:16:13
date last changed
2017-01-01 07:10:33
@article{31195177-15b2-451e-9b95-245a335fb95c,
  abstract     = {The objective of this investigation was to study regional absorption of inhaled insulin together with an enhancer (sodium di-octyl-sulfosuccinate [DOSS]) in the rabbit airways and lung. Insulin was administered with or without DOSS by aerosol inhalation, intratracheal infusion, intranasally, sublingually, and without DOSS intravenously. Blood glucose and plasma levels of insulin were measured during 100 min from the start of administration. Inhalation of insulin (3 U) with 0.25% or 1% DOSS decreased average blood glucose levels significantly more than inhalation of insulin (3 U) without DOSS. Intratracheal administration of 1.5 U of insulin with 0.25% DOSS in 0.3 mL of vehicle decreased the average blood glucose level significantly compared with intratracheal administration of 1.5 U of insulin and no DOSS in 0.3 mL of vehicle and compared with 1.5 U of insulin with 0.25% DOSS in 0.15 mL of vehicle. Intravenous insulin (1.5 U) and inhaled (1.5 U) insulin in 0.25% DOSS decreased average blood glucose levels significantly compared with intratracheal (0.15 mL), intranasal, and sublingual administration of 1.5 U of insulin with 0.25% DOSS. The bioavailability of inhaled insulin (1.5 U) with 0.25% DOSS was estimated to be 16% in comparison with 7% for intratracheally (0.15 mL), 1% intranasally, and 0.8% sublingually administered insulin (1.5 U with 0.25% DOSS), respectively. Inhaled insulin together with the absorption enhancer DOSS decreased the blood glucose level more effectively than insulin given intratracheally, intranasally, or sublingually. The effect on blood glucose reflected the difference in plasma insulin concentration for the different routes of administration.},
  author       = {Dahlback, M and Eirefelt, S and Backstrom, K and Larsson, P and Almér, Lars-Olof and Wollmer, Per and Jonson, Björn},
  issn         = {0894-2684},
  keyword      = {lung,insulin,enhancer,DOSS,airways,absorption,aerosol,rabbit},
  language     = {eng},
  number       = {1},
  pages        = {27--36},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Journal of Aerosol Medicine},
  title        = {Enhanced insulin absorption in the rabbit airways and lung by sodium dioctyl sulfosuccinate},
  url          = {http://dx.doi.org/10.1089/08942680252908557},
  volume       = {15},
  year         = {2002},
}