Gerronemins A-F, cytotoxic biscatechols from a Gerronema species
(2002) In Phytochemistry 59(6). p.643-648- Abstract
- The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.
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https://lup.lub.lu.se/record/340550
- author
- Silberborth, S ; Stumpf, A ; Erkel, G ; Anke, T and Sterner, Olov LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cytotoxic activity, biscatechols, Gerronema, gerronemins A-F
- in
- Phytochemistry
- volume
- 59
- issue
- 6
- pages
- 643 - 648
- publisher
- Elsevier
- external identifiers
-
- pmid:11867096
- wos:000174870800007
- scopus:0037085613
- ISSN
- 0031-9422
- DOI
- 10.1016/S0031-9422(02)00013-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 720d11f7-d7ee-44fd-8843-f097ba3fc19e (old id 340550)
- date added to LUP
- 2016-04-01 16:44:48
- date last changed
- 2022-02-27 23:22:32
@article{720d11f7-d7ee-44fd-8843-f097ba3fc19e, abstract = {{The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.}}, author = {{Silberborth, S and Stumpf, A and Erkel, G and Anke, T and Sterner, Olov}}, issn = {{0031-9422}}, keywords = {{cytotoxic activity; biscatechols; Gerronema; gerronemins A-F}}, language = {{eng}}, number = {{6}}, pages = {{643--648}}, publisher = {{Elsevier}}, series = {{Phytochemistry}}, title = {{Gerronemins A-F, cytotoxic biscatechols from a Gerronema species}}, url = {{http://dx.doi.org/10.1016/S0031-9422(02)00013-4}}, doi = {{10.1016/S0031-9422(02)00013-4}}, volume = {{59}}, year = {{2002}}, }