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Gerronemins A-F, cytotoxic biscatechols from a Gerronema species

Silberborth, S; Stumpf, A; Erkel, G; Anke, T and Sterner, Olov LU (2002) In Phytochemistry 59(6). p.643-648
Abstract
The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytotoxic activity, biscatechols, Gerronema, gerronemins A-F
in
Phytochemistry
volume
59
issue
6
pages
643 - 648
publisher
Elsevier
external identifiers
  • pmid:11867096
  • wos:000174870800007
  • scopus:0037085613
ISSN
0031-9422
DOI
10.1016/S0031-9422(02)00013-4
language
English
LU publication?
yes
id
720d11f7-d7ee-44fd-8843-f097ba3fc19e (old id 340550)
date added to LUP
2007-11-09 11:36:32
date last changed
2017-01-01 07:13:59
@article{720d11f7-d7ee-44fd-8843-f097ba3fc19e,
  abstract     = {The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.},
  author       = {Silberborth, S and Stumpf, A and Erkel, G and Anke, T and Sterner, Olov},
  issn         = {0031-9422},
  keyword      = {cytotoxic activity,biscatechols,Gerronema,gerronemins A-F},
  language     = {eng},
  number       = {6},
  pages        = {643--648},
  publisher    = {Elsevier},
  series       = {Phytochemistry},
  title        = {Gerronemins A-F, cytotoxic biscatechols from a Gerronema species},
  url          = {http://dx.doi.org/10.1016/S0031-9422(02)00013-4},
  volume       = {59},
  year         = {2002},
}