Deformability-based sorting of red blood cells in deterministic lateral displacement devices
(2016) 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 p.788-789- Abstract
Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/340a4e77-2930-45ae-a6be-42eb598ec6ba
- author
- Zhang, Z. LU ; Punyani, K. LU ; Henry, Ewan ; Holm, S. H. LU ; Beech, J. P. LU ; Tegenfeldt, J. O. LU ; Gompper, Gerhard and Fedosov, Dmitry A.
- organization
- publishing date
- 2016
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Bumper array, Mesoscopic simulation, Microfluidics, Post shape
- host publication
- 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
- pages
- 2 pages
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
- conference location
- Dublin, Ireland
- conference dates
- 2016-10-09 - 2016-10-13
- external identifiers
-
- scopus:85014203207
- ISBN
- 9780979806490
- language
- English
- LU publication?
- yes
- id
- 340a4e77-2930-45ae-a6be-42eb598ec6ba
- date added to LUP
- 2017-03-16 10:04:49
- date last changed
- 2023-09-07 01:08:54
@inproceedings{340a4e77-2930-45ae-a6be-42eb598ec6ba, abstract = {{<p>Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.</p>}}, author = {{Zhang, Z. and Punyani, K. and Henry, Ewan and Holm, S. H. and Beech, J. P. and Tegenfeldt, J. O. and Gompper, Gerhard and Fedosov, Dmitry A.}}, booktitle = {{20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016}}, isbn = {{9780979806490}}, keywords = {{Bumper array; Mesoscopic simulation; Microfluidics; Post shape}}, language = {{eng}}, pages = {{788--789}}, publisher = {{Chemical and Biological Microsystems Society}}, title = {{Deformability-based sorting of red blood cells in deterministic lateral displacement devices}}, year = {{2016}}, }