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Deformability-based sorting of red blood cells in deterministic lateral displacement devices

Zhang, Z. LU ; Punyani, K. LU ; Henry, Ewan; Holm, S. H. LU ; Beech, J. P. LU ; Tegenfeldt, J. O. LU ; Gompper, Gerhard and Fedosov, Dmitry A. (2016) 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 p.788-789
Abstract

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Bumper array, Mesoscopic simulation, Microfluidics, Post shape
in
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
external identifiers
  • scopus:85014203207
ISBN
9780979806490
language
English
LU publication?
yes
id
340a4e77-2930-45ae-a6be-42eb598ec6ba
date added to LUP
2017-03-16 10:04:49
date last changed
2017-03-20 09:48:08
@inproceedings{340a4e77-2930-45ae-a6be-42eb598ec6ba,
  abstract     = {<p>Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.</p>},
  author       = {Zhang, Z. and Punyani, K. and Henry, Ewan and Holm, S. H. and Beech, J. P. and Tegenfeldt, J. O. and Gompper, Gerhard and Fedosov, Dmitry A.},
  booktitle    = {20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016},
  isbn         = {9780979806490},
  keyword      = {Bumper array,Mesoscopic simulation,Microfluidics,Post shape},
  language     = {eng},
  pages        = {788--789},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Deformability-based sorting of red blood cells in deterministic lateral displacement devices},
  year         = {2016},
}