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Telomere terminating with centromere-specific repeats is closely associated with a transposon derived gene in Chironomus pallidivittatus

Rosén, Monika LU ; Castillejo-Lopez, Casimiro LU and Edström, Jan-Erik LU (2002) In Chromosoma 110(8). p.532-541
Abstract
We provide evidence that centromere-specific 155 bp DNA repeats terminate one pair of telomeres at the telocentric, left end of the short fourth chromosome in Chironomus pallidivittatus. Earlier evidence indicated that all other telomeres are terminated by 340 bp telomere-specific repeats. DNA that borders the 155 bp repeat contains a transcriptionally active 396 codon open reading frame (ORF) a few kilobases away from the repeat array. The conceptual product of the ORF has regions with similarities to transposase, DNA binding and endonuclease motifs and is likely to have an evolutionary origin in a transposon. It is flanked, within degenerate inverted repeats, by a modified form of an element. Cp80, that has previously been found to... (More)
We provide evidence that centromere-specific 155 bp DNA repeats terminate one pair of telomeres at the telocentric, left end of the short fourth chromosome in Chironomus pallidivittatus. Earlier evidence indicated that all other telomeres are terminated by 340 bp telomere-specific repeats. DNA that borders the 155 bp repeat contains a transcriptionally active 396 codon open reading frame (ORF) a few kilobases away from the repeat array. The conceptual product of the ORF has regions with similarities to transposase, DNA binding and endonuclease motifs and is likely to have an evolutionary origin in a transposon. It is flanked, within degenerate inverted repeats, by a modified form of an element. Cp80, that has previously been found to insert only into 155 bp repeats and that contains a putative CENP-B box and a region that is prone to recombine. The ORF may therefore have a functional relation to the centromeric region. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chromosoma
volume
110
issue
8
pages
532 - 541
publisher
Springer
external identifiers
  • pmid:12068970
  • wos:000174681400003
  • scopus:0036185473
ISSN
0009-5915
DOI
10.1007/s00412-001-0176-y
language
English
LU publication?
yes
id
0bab175a-a51a-401a-8a89-e92def93c370 (old id 341221)
date added to LUP
2007-11-12 12:35:50
date last changed
2017-01-01 07:01:11
@article{0bab175a-a51a-401a-8a89-e92def93c370,
  abstract     = {We provide evidence that centromere-specific 155 bp DNA repeats terminate one pair of telomeres at the telocentric, left end of the short fourth chromosome in Chironomus pallidivittatus. Earlier evidence indicated that all other telomeres are terminated by 340 bp telomere-specific repeats. DNA that borders the 155 bp repeat contains a transcriptionally active 396 codon open reading frame (ORF) a few kilobases away from the repeat array. The conceptual product of the ORF has regions with similarities to transposase, DNA binding and endonuclease motifs and is likely to have an evolutionary origin in a transposon. It is flanked, within degenerate inverted repeats, by a modified form of an element. Cp80, that has previously been found to insert only into 155 bp repeats and that contains a putative CENP-B box and a region that is prone to recombine. The ORF may therefore have a functional relation to the centromeric region.},
  author       = {Rosén, Monika and Castillejo-Lopez, Casimiro and Edström, Jan-Erik},
  issn         = {0009-5915},
  language     = {eng},
  number       = {8},
  pages        = {532--541},
  publisher    = {Springer},
  series       = {Chromosoma},
  title        = {Telomere terminating with centromere-specific repeats is closely associated with a transposon derived gene in Chironomus pallidivittatus},
  url          = {http://dx.doi.org/10.1007/s00412-001-0176-y},
  volume       = {110},
  year         = {2002},
}