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Geographic variations in possible risk factors for severe cardiac malformations

Cedergren, M; Selbing, A and Källén, Bengt LU (2002) In Acta Pædiatrica 91(2). p.222-228
Abstract
The aim of this study was to investigate various putative risk factors in a county in Sweden, described as having a 28% increased prevalence of cardiovascular malformations, and to compare them with the risk factors in two reference counties. Women giving birth in the studied counties differed in age and parity distribution, smoking, and educational level but these differences could not explain the increased risk of cardiovascular malformations in the county, since after stratification for these variables, the risk, estimate did not change substantially. A number of potential risk factors were studied in a case/control design: spontaneous abortions, involuntary childlessness, maternal disease, body mass index, medical drug use, alcohol... (More)
The aim of this study was to investigate various putative risk factors in a county in Sweden, described as having a 28% increased prevalence of cardiovascular malformations, and to compare them with the risk factors in two reference counties. Women giving birth in the studied counties differed in age and parity distribution, smoking, and educational level but these differences could not explain the increased risk of cardiovascular malformations in the county, since after stratification for these variables, the risk, estimate did not change substantially. A number of potential risk factors were studied in a case/control design: spontaneous abortions, involuntary childlessness, maternal disease, body mass index, medical drug use, alcohol use, parental employment, paternal age, and urban/rural residency. No single factor could be attributed to the increased rate, with the exception of living in a rural district, Nearly all risk factors, however, were stronger in the county studied than those in the reference counties (0.02 > p > 0.01). Conclusion: The only single putative risk factor that could have contributed to the increased risk for cardiac defects described in the county Studied was maternal residency in a rural district. Notably, nearly all potential risk factors studied were stronger in the counts studied compared with those in the reference area. A conceivable explanation is that one or more unidentified factors related to rural residency could potentiate prevalent and weak teratogenic risk factors for cardiac defects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rural, risk factor, malformation, cardiovascular, geographic
in
Acta Pædiatrica
volume
91
issue
2
pages
222 - 228
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000174331700020
  • pmid:11952013
  • scopus:0036195911
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2002.tb01699.x
language
English
LU publication?
yes
id
d47b26d6-1e72-4bf2-95ba-a3a07eae344b (old id 342170)
date added to LUP
2007-08-13 15:03:38
date last changed
2017-07-02 04:31:38
@article{d47b26d6-1e72-4bf2-95ba-a3a07eae344b,
  abstract     = {The aim of this study was to investigate various putative risk factors in a county in Sweden, described as having a 28% increased prevalence of cardiovascular malformations, and to compare them with the risk factors in two reference counties. Women giving birth in the studied counties differed in age and parity distribution, smoking, and educational level but these differences could not explain the increased risk of cardiovascular malformations in the county, since after stratification for these variables, the risk, estimate did not change substantially. A number of potential risk factors were studied in a case/control design: spontaneous abortions, involuntary childlessness, maternal disease, body mass index, medical drug use, alcohol use, parental employment, paternal age, and urban/rural residency. No single factor could be attributed to the increased rate, with the exception of living in a rural district, Nearly all risk factors, however, were stronger in the county studied than those in the reference counties (0.02 > p > 0.01). Conclusion: The only single putative risk factor that could have contributed to the increased risk for cardiac defects described in the county Studied was maternal residency in a rural district. Notably, nearly all potential risk factors studied were stronger in the counts studied compared with those in the reference area. A conceivable explanation is that one or more unidentified factors related to rural residency could potentiate prevalent and weak teratogenic risk factors for cardiac defects.},
  author       = {Cedergren, M and Selbing, A and Källén, Bengt},
  issn         = {1651-2227},
  keyword      = {rural,risk factor,malformation,cardiovascular,geographic},
  language     = {eng},
  number       = {2},
  pages        = {222--228},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Geographic variations in possible risk factors for severe cardiac malformations},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2002.tb01699.x},
  volume       = {91},
  year         = {2002},
}