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Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors

Johansson, Thomas; Soto Thompson, Marcelo LU ; Stenberg, Maria LU ; af Klinteberg, Claes; Andersson-Engels, Stefan LU ; Svanberg, Sune LU and Svanberg, Katarina LU (2002) In Applied Optics 41(7). p.1462-1468
Abstract
A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and... (More)
A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
41
issue
7
pages
1462 - 1468
publisher
OSA
external identifiers
  • wos:000174095600035
  • pmid:11900027
  • scopus:0036489389
ISSN
2155-3165
language
English
LU publication?
yes
id
92679dc5-eac8-4bf1-8d6b-4af8609a3654 (old id 343004)
date added to LUP
2007-10-31 13:05:00
date last changed
2017-01-01 04:23:37
@article{92679dc5-eac8-4bf1-8d6b-4af8609a3654,
  abstract     = {A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.},
  author       = {Johansson, Thomas and Soto Thompson, Marcelo and Stenberg, Maria and af Klinteberg, Claes and Andersson-Engels, Stefan and Svanberg, Sune and Svanberg, Katarina},
  issn         = {2155-3165},
  language     = {eng},
  number       = {7},
  pages        = {1462--1468},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors},
  volume       = {41},
  year         = {2002},
}