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Coeliac disease is associated with intrauterine growth and neonatal infections

Sandberg-Bennich, S; Dahlquist, G and Källén, Bengt LU (2002) In Acta Pædiatrica 91(1). p.30-33
Abstract
To investigate whether factors in the fetal or neonatal period influence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identified 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared with all children born in these years. Exposure variables: Maternal age, parity and smoking habits in early pregnancy, preeclampsia, pregnancy duration and birthweight, birthweight by gestational week, Apgar score, neonatal icterus, neonatal infections, maternal-fetal blood group incompatibility, exchange transfusion. phototherapy. Odds ratios and... (More)
To investigate whether factors in the fetal or neonatal period influence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identified 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared with all children born in these years. Exposure variables: Maternal age, parity and smoking habits in early pregnancy, preeclampsia, pregnancy duration and birthweight, birthweight by gestational week, Apgar score, neonatal icterus, neonatal infections, maternal-fetal blood group incompatibility, exchange transfusion. phototherapy. Odds ratios and test-based confidence intervals were calculated. Analyses were made with stratification for year of birth and other risk factors. The risk of developing coeliac disease decreased with maternal age and was lower in first-born than in second-born children. Maternal smoking in early pregnancy was a weak risk factor, as was low birthweight. The most evident risk factors were being exposed to neonatal infections (OR = 1.52. confidence limits 1.19: 1.95) and being small for gestational age (OR = 1.45, confidence limits 1.20: 1.75). These risk factors were independent of each other. Conclusions: We have demonstrated that the intrauterine environment. mainly as mirrored by a low birthweight for gestational age and, independently, neonatal infection diagnosis, is associated with the risk of developing coeliac disease, supporting the idea of a multifactorial aetiology of the disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
maternal age, coeliac disease, growth retardation, smoking
in
Acta Pædiatrica
volume
91
issue
1
pages
30 - 33
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000173762500007
  • pmid:11883814
  • scopus:0036177436
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2002.tb01635.x
language
English
LU publication?
yes
id
2df5937c-4d3a-4061-9354-9e4a4402ec07 (old id 343624)
date added to LUP
2007-11-12 14:25:01
date last changed
2017-12-10 04:37:20
@article{2df5937c-4d3a-4061-9354-9e4a4402ec07,
  abstract     = {To investigate whether factors in the fetal or neonatal period influence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identified 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared with all children born in these years. Exposure variables: Maternal age, parity and smoking habits in early pregnancy, preeclampsia, pregnancy duration and birthweight, birthweight by gestational week, Apgar score, neonatal icterus, neonatal infections, maternal-fetal blood group incompatibility, exchange transfusion. phototherapy. Odds ratios and test-based confidence intervals were calculated. Analyses were made with stratification for year of birth and other risk factors. The risk of developing coeliac disease decreased with maternal age and was lower in first-born than in second-born children. Maternal smoking in early pregnancy was a weak risk factor, as was low birthweight. The most evident risk factors were being exposed to neonatal infections (OR = 1.52. confidence limits 1.19: 1.95) and being small for gestational age (OR = 1.45, confidence limits 1.20: 1.75). These risk factors were independent of each other. Conclusions: We have demonstrated that the intrauterine environment. mainly as mirrored by a low birthweight for gestational age and, independently, neonatal infection diagnosis, is associated with the risk of developing coeliac disease, supporting the idea of a multifactorial aetiology of the disease.},
  author       = {Sandberg-Bennich, S and Dahlquist, G and Källén, Bengt},
  issn         = {1651-2227},
  keyword      = {maternal age,coeliac disease,growth retardation,smoking},
  language     = {eng},
  number       = {1},
  pages        = {30--33},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Coeliac disease is associated with intrauterine growth and neonatal infections},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2002.tb01635.x},
  volume       = {91},
  year         = {2002},
}