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The influence of hormonal status and features of the metabolic syndrome on bone density: A population-based study of Swedish women aged 50 to 59 years. The women's health in the Lund area study

Lidfeldt, Jonas LU ; Holmdahl, Lydia LU ; Samsioe, Göran LU ; Nerbrand, Christina LU ; Nyberg, Per LU ; Scherstén, Bengt LU and Agardh, Carl-David LU (2002) In Metabolism, Clinical and Experimental 51(2). p.267-270
Abstract
This study investigated whether there is an association between bone density and features of the metabolic syndrome in relation to hormonal status. All women aged 50 to 59 years living in a defined geographic area in Sweden were offered a health assessment program including blood glucose, lipid profile, blood pressure, and bone densitometry. Women were divided into 3 groups according to their hormonal status: premenopausal (PM), postmenopausal with hormone replacement therapy (PMT), and postmenopausal without hormone replacement therapy (PMO). Of the 6,886 women investigated, 7% were PM, 41% PMT, and 52% PMO. The overall prevalence of osteopenia and osteoporosis, according to the World Health Organization (WHO) definition, was 42.6% and... (More)
This study investigated whether there is an association between bone density and features of the metabolic syndrome in relation to hormonal status. All women aged 50 to 59 years living in a defined geographic area in Sweden were offered a health assessment program including blood glucose, lipid profile, blood pressure, and bone densitometry. Women were divided into 3 groups according to their hormonal status: premenopausal (PM), postmenopausal with hormone replacement therapy (PMT), and postmenopausal without hormone replacement therapy (PMO). Of the 6,886 women investigated, 7% were PM, 41% PMT, and 52% PMO. The overall prevalence of osteopenia and osteoporosis, according to the World Health Organization (WHO) definition, was 42.6% and 6.6%, respectively. T-score in the PM group was higher than in the PMT (P <.05) and PMO groups (P <.001) and higher in the PMT group compared with the PMO group (P <.001). Also, in the total cohort, the bone density was positively associated with body weight, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum triglycerides, and blood glucose (P <.001 for all) and negatively associated with serum levels of cholesterol (P <.05) and high-density lipoprotein (HDL) (P <.001). This was most evident among the PMO women, suggesting that the influence of metabolic factors on bone density increases when the levels of hormones decrease. This indicates that hormone replacement therapy maintains treated women in a premenopausal status concerning the metabolic factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Metabolism, Clinical and Experimental
volume
51
issue
2
pages
267 - 270
publisher
Elsevier
external identifiers
  • pmid:11833060
  • wos:000173738800023
  • scopus:0036180503
ISSN
1532-8600
DOI
10.1053/meta.2002.300001
language
English
LU publication?
yes
id
1ff33668-12e3-4a53-b58e-d1d8d41a737d (old id 343766)
date added to LUP
2007-11-14 14:07:06
date last changed
2017-11-05 04:33:26
@article{1ff33668-12e3-4a53-b58e-d1d8d41a737d,
  abstract     = {This study investigated whether there is an association between bone density and features of the metabolic syndrome in relation to hormonal status. All women aged 50 to 59 years living in a defined geographic area in Sweden were offered a health assessment program including blood glucose, lipid profile, blood pressure, and bone densitometry. Women were divided into 3 groups according to their hormonal status: premenopausal (PM), postmenopausal with hormone replacement therapy (PMT), and postmenopausal without hormone replacement therapy (PMO). Of the 6,886 women investigated, 7% were PM, 41% PMT, and 52% PMO. The overall prevalence of osteopenia and osteoporosis, according to the World Health Organization (WHO) definition, was 42.6% and 6.6%, respectively. T-score in the PM group was higher than in the PMT (P &lt;.05) and PMO groups (P &lt;.001) and higher in the PMT group compared with the PMO group (P &lt;.001). Also, in the total cohort, the bone density was positively associated with body weight, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum triglycerides, and blood glucose (P &lt;.001 for all) and negatively associated with serum levels of cholesterol (P &lt;.05) and high-density lipoprotein (HDL) (P &lt;.001). This was most evident among the PMO women, suggesting that the influence of metabolic factors on bone density increases when the levels of hormones decrease. This indicates that hormone replacement therapy maintains treated women in a premenopausal status concerning the metabolic factors.},
  author       = {Lidfeldt, Jonas and Holmdahl, Lydia and Samsioe, Göran and Nerbrand, Christina and Nyberg, Per and Scherstén, Bengt and Agardh, Carl-David},
  issn         = {1532-8600},
  language     = {eng},
  number       = {2},
  pages        = {267--270},
  publisher    = {Elsevier},
  series       = {Metabolism, Clinical and Experimental},
  title        = {The influence of hormonal status and features of the metabolic syndrome on bone density: A population-based study of Swedish women aged 50 to 59 years. The women's health in the Lund area study},
  url          = {http://dx.doi.org/10.1053/meta.2002.300001},
  volume       = {51},
  year         = {2002},
}