Advanced

Neurological sequelae in children born after in-vitro fertilisation: a population-based study

Strömberg, B; Dahlquist, G; Ericson, A; Finnstrom, O; Koster, M and Stjernqvist, Karin LU (2002) In The Lancet 359(9305). p.461-465
Abstract
Background There is an absence of population-based long-term studies on the risk of neurological sequelae in children born after in-vitro fertilisation (IVF). Our aim was to compare the frequency of such problems between IVF-born children and controls. Methods We did a population-based retrospective cohort study in which we compared development of neurological problems in 5680 children born after IVF, with 11 360 matched controls. For 2060 twins born after IVF, a second set of controls (n=4120), all twins, were selected. We obtained data on neurological problems from the records of the Swedish habilitation centres. Findings Children born after IVF are more likely to need habilitation services than controls (odds ratio 1.7, 95% Cl 1.3-2.2).... (More)
Background There is an absence of population-based long-term studies on the risk of neurological sequelae in children born after in-vitro fertilisation (IVF). Our aim was to compare the frequency of such problems between IVF-born children and controls. Methods We did a population-based retrospective cohort study in which we compared development of neurological problems in 5680 children born after IVF, with 11 360 matched controls. For 2060 twins born after IVF, a second set of controls (n=4120), all twins, were selected. We obtained data on neurological problems from the records of the Swedish habilitation centres. Findings Children born after IVF are more likely to need habilitation services than controls (odds ratio 1.7, 95% Cl 1.3-2.2). For singletons, the risk was 1.4 (1.0-2.1). The most common neurological diagnosis was cerebral palsy, for which children born after IVF had an increased risk of 3.7 (2.0-6.6), and IVF singletons of 2.8 (1.3-5.8). Suspected developmental delay was increased four-fold (1.9-8.3) in children born after IVF. Twins born after IVF did not differ from control twins with respect to risk of neurological sequelae. Low-birthweight and premature infants were more likely to need habilitation than fullterm babies. Maternal age did not affect risk. Interpretation Our study suggests that children born after IVF have an increased risk of developing neurological problems, especially cerebral palsy. These risks are largely due to the high frequency of twin pregnancies, low birthweight, and prematurity among babies born after IVF. To limit these risks, we recommend that only one embryo should be transferred during IVF. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
359
issue
9305
pages
461 - 465
publisher
Elsevier Limited
external identifiers
  • pmid:11853790
  • wos:000173785600007
  • scopus:0037045588
ISSN
1474-547X
DOI
10.1016/S0140-6736(02)07674-2
language
English
LU publication?
yes
id
0d0330c8-5b1e-42c2-a7bc-9086eccdf34f (old id 343782)
date added to LUP
2007-11-09 12:40:47
date last changed
2017-12-10 03:45:13
@article{0d0330c8-5b1e-42c2-a7bc-9086eccdf34f,
  abstract     = {Background There is an absence of population-based long-term studies on the risk of neurological sequelae in children born after in-vitro fertilisation (IVF). Our aim was to compare the frequency of such problems between IVF-born children and controls. Methods We did a population-based retrospective cohort study in which we compared development of neurological problems in 5680 children born after IVF, with 11 360 matched controls. For 2060 twins born after IVF, a second set of controls (n=4120), all twins, were selected. We obtained data on neurological problems from the records of the Swedish habilitation centres. Findings Children born after IVF are more likely to need habilitation services than controls (odds ratio 1.7, 95% Cl 1.3-2.2). For singletons, the risk was 1.4 (1.0-2.1). The most common neurological diagnosis was cerebral palsy, for which children born after IVF had an increased risk of 3.7 (2.0-6.6), and IVF singletons of 2.8 (1.3-5.8). Suspected developmental delay was increased four-fold (1.9-8.3) in children born after IVF. Twins born after IVF did not differ from control twins with respect to risk of neurological sequelae. Low-birthweight and premature infants were more likely to need habilitation than fullterm babies. Maternal age did not affect risk. Interpretation Our study suggests that children born after IVF have an increased risk of developing neurological problems, especially cerebral palsy. These risks are largely due to the high frequency of twin pregnancies, low birthweight, and prematurity among babies born after IVF. To limit these risks, we recommend that only one embryo should be transferred during IVF.},
  author       = {Strömberg, B and Dahlquist, G and Ericson, A and Finnstrom, O and Koster, M and Stjernqvist, Karin},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9305},
  pages        = {461--465},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Neurological sequelae in children born after in-vitro fertilisation: a population-based study},
  url          = {http://dx.doi.org/10.1016/S0140-6736(02)07674-2},
  volume       = {359},
  year         = {2002},
}