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Neuroendocrine abnormalities in Parkinson's disease

De Pablo-Fernández, Eduardo; Breen, David P; Bouloux, Pierre M; Barker, Roger A LU ; Foltynie, Thomas and Warner, Thomas T (2017) In Journal of Neurology, Neurosurgery and Psychiatry 88. p.176-185
Abstract

Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their role in overall phenotype. We discuss pathophysiological mechanisms, clinical implications,... (More)

Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their role in overall phenotype. We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharmacological interventions based on the current evidence. We also review recent advances in the field, focusing on the potential targets for development of neuroprotective drugs in Parkinson's disease and suggest future areas for research.

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author
organization
publishing date
type
Contribution to journal
publication status
published
in
Journal of Neurology, Neurosurgery and Psychiatry
volume
88
pages
176 - 185
publisher
BMJ Publishing Group
external identifiers
  • scopus:84994884945
ISSN
1468-330X
DOI
10.1136/jnnp-2016-314601
language
English
LU publication?
no
id
343e2059-f3aa-4778-b36e-cc1e3cbaf740
date added to LUP
2016-11-23 13:00:46
date last changed
2018-11-11 04:46:28
@article{343e2059-f3aa-4778-b36e-cc1e3cbaf740,
  abstract     = {<p>Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their role in overall phenotype. We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharmacological interventions based on the current evidence. We also review recent advances in the field, focusing on the potential targets for development of neuroprotective drugs in Parkinson's disease and suggest future areas for research.</p>},
  author       = {De Pablo-Fernández, Eduardo and Breen, David P and Bouloux, Pierre M and Barker, Roger A and Foltynie, Thomas and Warner, Thomas T},
  issn         = {1468-330X},
  language     = {eng},
  pages        = {176--185},
  publisher    = {BMJ Publishing Group},
  series       = {Journal of Neurology, Neurosurgery and Psychiatry},
  title        = {Neuroendocrine abnormalities in Parkinson's disease},
  url          = {http://dx.doi.org/10.1136/jnnp-2016-314601},
  volume       = {88},
  year         = {2017},
}