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Synthesis of podoscyphic acid

Eriksson Bajtner, Johan LU ; Johansson, Martin H LU and Sterner, Olov LU (2002) In Tetrahedron Letters 43(5). p.891-893
Abstract
Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enzymatic hydrolysis, podoscyphic acid, synthesis lipase
in
Tetrahedron Letters
volume
43
issue
5
pages
891 - 893
publisher
Elsevier
external identifiers
  • wos:000173596400038
  • scopus:0037185505
ISSN
0040-4039
DOI
10.1016/S0040-4039(01)02264-X
language
English
LU publication?
yes
id
4319199c-a88a-4849-99cb-cfab4b750ba8 (old id 344033)
date added to LUP
2007-08-17 09:22:41
date last changed
2017-01-01 06:48:42
@article{4319199c-a88a-4849-99cb-cfab4b750ba8,
  abstract     = {Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.},
  author       = {Eriksson Bajtner, Johan and Johansson, Martin H and Sterner, Olov},
  issn         = {0040-4039},
  keyword      = {enzymatic hydrolysis,podoscyphic acid,synthesis lipase},
  language     = {eng},
  number       = {5},
  pages        = {891--893},
  publisher    = {Elsevier},
  series       = {Tetrahedron Letters},
  title        = {Synthesis of podoscyphic acid},
  url          = {http://dx.doi.org/10.1016/S0040-4039(01)02264-X},
  volume       = {43},
  year         = {2002},
}