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Changes of the uterine proteoglycan distribution at term pregnancy and during labour

Hjelm, AM; Barchan, K; Malmström, Anders LU and Ekman-Ordeberg, GE (2002) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 100(2). p.146-151
Abstract
Objective: To characterise uterine proteoglycans and changes therein during pregnancy and labour. Study Design: Uterine samples were collected from 6 non-pregnant, 10 term-pregnant and from 10 women in active tabour. The proteoglycans were extracted by 4 M guanidine hydrochloride and precipitated with Alcian Blue. They were separated by electrophoresis and identified by Western blotting. Results: Decorin was the dominating proteoalycan and smaller amounts of biglycan was found. A considerable amount of heparan sulphate proteoglycans wag also detected. Decorin and biglycan decreased by 40% until term. The amount of heparan sulphate proteoglycans increased by 46% during active labour. Conclusion: Our data indicate that a considerable... (More)
Objective: To characterise uterine proteoglycans and changes therein during pregnancy and labour. Study Design: Uterine samples were collected from 6 non-pregnant, 10 term-pregnant and from 10 women in active tabour. The proteoglycans were extracted by 4 M guanidine hydrochloride and precipitated with Alcian Blue. They were separated by electrophoresis and identified by Western blotting. Results: Decorin was the dominating proteoalycan and smaller amounts of biglycan was found. A considerable amount of heparan sulphate proteoglycans wag also detected. Decorin and biglycan decreased by 40% until term. The amount of heparan sulphate proteoglycans increased by 46% during active labour. Conclusion: Our data indicate that a considerable remodelling of the uterine connective tissue occurs during pregnancy and labour. The decrease of decorin and biglycan and the increase of heparan sulphate proteoglycans may be important for normal myometrial contractions during tabour. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
uterus, proteoglycans, labour, pregnancy
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
100
issue
2
pages
146 - 151
publisher
Elsevier
external identifiers
  • wos:000173465500006
  • pmid:11750954
  • scopus:0037049961
ISSN
0301-2115
DOI
10.1016/S0301-2115(01)00476-6
language
English
LU publication?
yes
id
3cff942d-6597-4f95-ba91-6605551346c4 (old id 344486)
date added to LUP
2007-10-22 09:19:58
date last changed
2017-09-17 05:03:43
@article{3cff942d-6597-4f95-ba91-6605551346c4,
  abstract     = {Objective: To characterise uterine proteoglycans and changes therein during pregnancy and labour. Study Design: Uterine samples were collected from 6 non-pregnant, 10 term-pregnant and from 10 women in active tabour. The proteoglycans were extracted by 4 M guanidine hydrochloride and precipitated with Alcian Blue. They were separated by electrophoresis and identified by Western blotting. Results: Decorin was the dominating proteoalycan and smaller amounts of biglycan was found. A considerable amount of heparan sulphate proteoglycans wag also detected. Decorin and biglycan decreased by 40% until term. The amount of heparan sulphate proteoglycans increased by 46% during active labour. Conclusion: Our data indicate that a considerable remodelling of the uterine connective tissue occurs during pregnancy and labour. The decrease of decorin and biglycan and the increase of heparan sulphate proteoglycans may be important for normal myometrial contractions during tabour. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.},
  author       = {Hjelm, AM and Barchan, K and Malmström, Anders and Ekman-Ordeberg, GE},
  issn         = {0301-2115},
  keyword      = {uterus,proteoglycans,labour,pregnancy},
  language     = {eng},
  number       = {2},
  pages        = {146--151},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Changes of the uterine proteoglycan distribution at term pregnancy and during labour},
  url          = {http://dx.doi.org/10.1016/S0301-2115(01)00476-6},
  volume       = {100},
  year         = {2002},
}