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Autologous chondrocyte transplantation - Biomechanics and long-term durability

Peterson, L; Brittberg, M; Kiviranta, I; Lundgren-Åkerlund, Evy LU and Lindahl, A (2002) In American Journal of Sports Medicine 30(1). p.2-12
Abstract
We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of... (More)
We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I Collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
American Journal of Sports Medicine
volume
30
issue
1
pages
2 - 12
publisher
American Orthopaedic Society for Sports Medicine
external identifiers
  • wos:000173349800002
  • scopus:0036155852
ISSN
1552-3365
language
English
LU publication?
yes
id
15c6cf90-cda6-4c22-9774-d7f077e0b1ae (old id 344612)
alternative location
http://ajs.sagepub.com/cgi/content/abstract/30/1/2
date added to LUP
2007-11-08 15:42:41
date last changed
2017-12-10 04:40:35
@article{15c6cf90-cda6-4c22-9774-d7f077e0b1ae,
  abstract     = {We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I Collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years.},
  author       = {Peterson, L and Brittberg, M and Kiviranta, I and Lundgren-Åkerlund, Evy and Lindahl, A},
  issn         = {1552-3365},
  language     = {eng},
  number       = {1},
  pages        = {2--12},
  publisher    = {American Orthopaedic Society for Sports Medicine},
  series       = {American Journal of Sports Medicine},
  title        = {Autologous chondrocyte transplantation - Biomechanics and long-term durability},
  volume       = {30},
  year         = {2002},
}