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A novel blood-based biomarker for detection of autism spectrum disorders.

N, Momeni; J, Bergquist; F, Behnia; Sivberg, Bengt LU ; M. T., Joghataei and B. L., Persson (2012) In Translational Psychiatry 2(3). p.91-91
Abstract
Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel... (More)
Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Translational Psychiatry
volume
2
issue
3
pages
91 - 91
publisher
Nature Publishing Group
external identifiers
  • wos:000315990800007
  • scopus:84858021906
ISSN
2158-3188
DOI
10.1038/tp.2012.19
language
English
LU publication?
yes
id
9b968858-61c5-45b6-9770-7dea022a2f77 (old id 3459575)
alternative location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309533/
date added to LUP
2013-02-08 12:53:38
date last changed
2017-10-29 03:48:49
@article{9b968858-61c5-45b6-9770-7dea022a2f77,
  abstract     = {Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD},
  author       = {N, Momeni and J, Bergquist and F, Behnia and Sivberg, Bengt and M. T., Joghataei and B. L., Persson},
  issn         = {2158-3188},
  language     = {eng},
  number       = {3},
  pages        = {91--91},
  publisher    = {Nature Publishing Group},
  series       = {Translational Psychiatry},
  title        = {A novel blood-based biomarker for detection of autism spectrum disorders.},
  url          = {http://dx.doi.org/10.1038/tp.2012.19},
  volume       = {2},
  year         = {2012},
}