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Nanomodified surfaces and neurite outgrowth

Kanje, Martin LU and Johansson, Fredrik LU (2011) In Progress in Brain Research 194. p.253-262
Abstract
Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be... (More)
Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be applied to guide neurite outgrowth on implants in the nervous system intended for recordings of electrical and/or chemical activities. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nanostructured materials, nerve regeneration, ganglia DRG, neurite, electrodes, implants
in
Progress in Brain Research
volume
194
pages
253 - 262
publisher
Elsevier
external identifiers
  • wos:000311038900020
  • scopus:80051873976
ISSN
1875-7855
DOI
10.1016/B978-0-444-53815-4.00002-9
language
English
LU publication?
yes
id
dd1224f2-bc36-4e8e-bc23-7ba4a54c24aa (old id 3470369)
date added to LUP
2013-02-20 13:55:38
date last changed
2017-08-13 03:57:33
@article{dd1224f2-bc36-4e8e-bc23-7ba4a54c24aa,
  abstract     = {Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be applied to guide neurite outgrowth on implants in the nervous system intended for recordings of electrical and/or chemical activities.},
  author       = {Kanje, Martin and Johansson, Fredrik},
  issn         = {1875-7855},
  keyword      = {nanostructured materials,nerve regeneration,ganglia DRG,neurite,electrodes,implants},
  language     = {eng},
  pages        = {253--262},
  publisher    = {Elsevier},
  series       = {Progress in Brain Research},
  title        = {Nanomodified surfaces and neurite outgrowth},
  url          = {http://dx.doi.org/10.1016/B978-0-444-53815-4.00002-9},
  volume       = {194},
  year         = {2011},
}