Long-term improvements after mindfulness-based group therapy of depression, anxiety and stress and adjustment disorders : A randomized controlled trial
(2019) In Early Intervention in Psychiatry 13(4). p.943-952- Abstract
Background: Although mindfulness-based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long-term improvements after such therapies in these common psychiatric disorders. Methods: Two hundred and fifteen patients were randomized in a randomized clinical trial (RCT) (ClinicalTrials.gov ID: NCT01476371) conducted in 2012 at 16 primary healthcare centres in southern Sweden. The patients were randomized to MGT or treatment as usual (TAU) and completed four psychometric self-rated scales after 8 weeks of treatment. Approximately 12months after the completion of the 8-week treatment, the same scales were repeated. Ordinal and generalized... (More)
Background: Although mindfulness-based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long-term improvements after such therapies in these common psychiatric disorders. Methods: Two hundred and fifteen patients were randomized in a randomized clinical trial (RCT) (ClinicalTrials.gov ID: NCT01476371) conducted in 2012 at 16 primary healthcare centres in southern Sweden. The patients were randomized to MGT or treatment as usual (TAU) and completed four psychometric self-rated scales after 8 weeks of treatment. Approximately 12months after the completion of the 8-week treatment, the same scales were repeated. Ordinal and generalized linear-mixed models, adjusted for cluster effects, were used for the analysis. Results: For all four psychometric scales (MADRS-S [Montgomery-Åsberg Depression Rating Scale-S], HADS-D, HADS-A [Hospital Anxiety and Depression Scale A and D] and PHQ-9 [Patient Health Questionnaire-9]) the scores at the 1-year follow-up were significantly improved (all P values <0.001) in both groups. Furthermore, there were no significant differences between the MGT and TAU in the psychometric scores at the 1-year follow-up. Conclusions: To the best of our knowledge, this is the first RCT comparing the long-term improvements after MGT with TAU. Although it cannot be excluded that our findings are a result of the natural course of common psychiatric disorders or other factors, they suggest a long-term positive improvement after both MGT and TAU.
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- author
- Sundquist, Jan LU ; Palmér, Karolina LU ; Memon, Ashfaque A. LU ; Wang, Xiao LU ; Johansson, Leena M. LU and Sundquist, Kristina LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anxiety, Depression, Mindfulness, Primary healthcare, Randomized controlled trial
- in
- Early Intervention in Psychiatry
- volume
- 13
- issue
- 4
- pages
- 943 - 952
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85050503790
- pmid:29968371
- ISSN
- 1751-7885
- DOI
- 10.1111/eip.12715
- project
- Molecular mechanism associated with response to psychotherapeutic interventions in patients with depression/anxiety in primary care patients
- language
- English
- LU publication?
- yes
- id
- 34993af1-b1bf-4cb0-9100-8aa7826fde58
- date added to LUP
- 2018-09-18 15:07:01
- date last changed
- 2024-09-03 01:24:19
@article{34993af1-b1bf-4cb0-9100-8aa7826fde58, abstract = {{<p>Background: Although mindfulness-based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long-term improvements after such therapies in these common psychiatric disorders. Methods: Two hundred and fifteen patients were randomized in a randomized clinical trial (RCT) (ClinicalTrials.gov ID: NCT01476371) conducted in 2012 at 16 primary healthcare centres in southern Sweden. The patients were randomized to MGT or treatment as usual (TAU) and completed four psychometric self-rated scales after 8 weeks of treatment. Approximately 12months after the completion of the 8-week treatment, the same scales were repeated. Ordinal and generalized linear-mixed models, adjusted for cluster effects, were used for the analysis. Results: For all four psychometric scales (MADRS-S [Montgomery-Åsberg Depression Rating Scale-S], HADS-D, HADS-A [Hospital Anxiety and Depression Scale A and D] and PHQ-9 [Patient Health Questionnaire-9]) the scores at the 1-year follow-up were significantly improved (all P values <0.001) in both groups. Furthermore, there were no significant differences between the MGT and TAU in the psychometric scores at the 1-year follow-up. Conclusions: To the best of our knowledge, this is the first RCT comparing the long-term improvements after MGT with TAU. Although it cannot be excluded that our findings are a result of the natural course of common psychiatric disorders or other factors, they suggest a long-term positive improvement after both MGT and TAU.</p>}}, author = {{Sundquist, Jan and Palmér, Karolina and Memon, Ashfaque A. and Wang, Xiao and Johansson, Leena M. and Sundquist, Kristina}}, issn = {{1751-7885}}, keywords = {{Anxiety; Depression; Mindfulness; Primary healthcare; Randomized controlled trial}}, language = {{eng}}, number = {{4}}, pages = {{943--952}}, publisher = {{Wiley-Blackwell}}, series = {{Early Intervention in Psychiatry}}, title = {{Long-term improvements after mindfulness-based group therapy of depression, anxiety and stress and adjustment disorders : A randomized controlled trial}}, url = {{http://dx.doi.org/10.1111/eip.12715}}, doi = {{10.1111/eip.12715}}, volume = {{13}}, year = {{2019}}, }