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Immunohistochemical investigation of prognostic biomarkers in resected colorectal liver metastases : A systematic review and meta-analysis

Torén, William LU ; Ansari, Daniel LU and Andersson, Roland LU (2018) In Cancer Cell International 18(1).
Abstract

Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed according to the PRISMA guidelines. Articles were identified in the PubMed database with selected search terms and by cross-references search. The REMARK quality criteria were applied. Markers were included if they reported the prognostic impact of immunohistochemical markers in a multivariable setting in relation to overall survival (OS). A... (More)

Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed according to the PRISMA guidelines. Articles were identified in the PubMed database with selected search terms and by cross-references search. The REMARK quality criteria were applied. Markers were included if they reported the prognostic impact of immunohistochemical markers in a multivariable setting in relation to overall survival (OS). A meta-analysis was conducted when more than one original article provided survival data of a marker. Results: In total, 26 biomarkers were identified as independent significant markers for OS in resected CRLM. These biomarkers were found to be involved in multiple oncogenic signalling pathways that control cell growth, apoptosis, angiogenesis and evasion of immune detection. Among these biomarker candidates were Ki-67, EGFR, p53, hTERT, CD34, TSP-1, KISS1, Aurora kinase A and CDX2. CD34 and TSP-1 were reported as significantly associated with survival by more than one study and where therefore pooled in a meta-analysis. Conclusion: A number of independent prognostic biomarkers for resected CRLM were identified. However, most markers were evaluated in a retrospective setting with small patient cohorts, without external validation. Large, prospective, multicentre studies with standardised methods are needed before biomarkers can translated into the clinic.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Colorectal liver metastasis, Immunohistochemistry, Prognosis, Tissue microarray
in
Cancer Cell International
volume
18
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85059329272
ISSN
1475-2867
DOI
10.1186/s12935-018-0715-8
language
English
LU publication?
yes
id
34c639b1-6d60-4367-861d-63a56ea99236
date added to LUP
2019-01-11 12:51:06
date last changed
2019-02-20 11:42:42
@article{34c639b1-6d60-4367-861d-63a56ea99236,
  abstract     = {<p>Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed according to the PRISMA guidelines. Articles were identified in the PubMed database with selected search terms and by cross-references search. The REMARK quality criteria were applied. Markers were included if they reported the prognostic impact of immunohistochemical markers in a multivariable setting in relation to overall survival (OS). A meta-analysis was conducted when more than one original article provided survival data of a marker. Results: In total, 26 biomarkers were identified as independent significant markers for OS in resected CRLM. These biomarkers were found to be involved in multiple oncogenic signalling pathways that control cell growth, apoptosis, angiogenesis and evasion of immune detection. Among these biomarker candidates were Ki-67, EGFR, p53, hTERT, CD34, TSP-1, KISS1, Aurora kinase A and CDX2. CD34 and TSP-1 were reported as significantly associated with survival by more than one study and where therefore pooled in a meta-analysis. Conclusion: A number of independent prognostic biomarkers for resected CRLM were identified. However, most markers were evaluated in a retrospective setting with small patient cohorts, without external validation. Large, prospective, multicentre studies with standardised methods are needed before biomarkers can translated into the clinic.</p>},
  articleno    = {217},
  author       = {Torén, William and Ansari, Daniel and Andersson, Roland},
  issn         = {1475-2867},
  keyword      = {Biomarkers,Colorectal liver metastasis,Immunohistochemistry,Prognosis,Tissue microarray},
  language     = {eng},
  month        = {12},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Cancer Cell International},
  title        = {Immunohistochemical investigation of prognostic biomarkers in resected colorectal liver metastases : A systematic review and meta-analysis},
  url          = {http://dx.doi.org/10.1186/s12935-018-0715-8},
  volume       = {18},
  year         = {2018},
}