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Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer

Lascorz, Jess; Bevier, Melanie; v. Schoenfels, Witigo; Kalthoff, Holger; Aselmann, Heiko; Beckmann, Jan; Egberts, Jan; Buch, Stephan; Becker, Thomas and Schreiber, Stefan, et al. (2013) In International Journal of Colorectal Disease 28(2). p.173-181
Abstract
We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with disease progression and survival. The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR = 2.18, 95 % CI 1.10-4.33, CC versus AA) and with overall survival (HR = 1.99, 95 % CI 1.04-3.81, CC versus AA). This association remained significant after adjustment for age at diagnosis, tumour stage (T) and... (More)
We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with disease progression and survival. The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR = 2.18, 95 % CI 1.10-4.33, CC versus AA) and with overall survival (HR = 1.99, 95 % CI 1.04-3.81, CC versus AA). This association remained significant after adjustment for age at diagnosis, tumour stage (T) and lymph node status (N). Three polymorphisms in CD47 were associated with distant metastasis in a dominant model: rs9879947 and rs3206652 in the 3'-UTR (OR = 1.64, 95 % CI 1.01-2.64 and OR = 1.88, 95 % CI 1.27-2.80, respectively) and the eSNP rs3804639 (OR = 1.73, 95 % CI 1.17-2.57). The novel associations of eSNPs in CD47 with worse survival and distant metastasis should be confirmed by additional studies, since increased expression of this gene has recently been shown to be an indicator of poor prognosis in cancer patients. (Less)
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published
subject
keywords
CD47, Colorectal cancer, Extracellular matrix, Prognosis, Survival
in
International Journal of Colorectal Disease
volume
28
issue
2
pages
173 - 181
publisher
Springer
external identifiers
  • wos:000315359000003
  • scopus:84879500150
ISSN
1432-1262
DOI
10.1007/s00384-012-1541-4
language
English
LU publication?
yes
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3502227a-615b-4b5e-99a8-0e67e8379ea5 (old id 3674620)
date added to LUP
2013-05-02 08:59:12
date last changed
2019-02-20 02:08:05
@article{3502227a-615b-4b5e-99a8-0e67e8379ea5,
  abstract     = {We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with disease progression and survival. The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR = 2.18, 95 % CI 1.10-4.33, CC versus AA) and with overall survival (HR = 1.99, 95 % CI 1.04-3.81, CC versus AA). This association remained significant after adjustment for age at diagnosis, tumour stage (T) and lymph node status (N). Three polymorphisms in CD47 were associated with distant metastasis in a dominant model: rs9879947 and rs3206652 in the 3'-UTR (OR = 1.64, 95 % CI 1.01-2.64 and OR = 1.88, 95 % CI 1.27-2.80, respectively) and the eSNP rs3804639 (OR = 1.73, 95 % CI 1.17-2.57). The novel associations of eSNPs in CD47 with worse survival and distant metastasis should be confirmed by additional studies, since increased expression of this gene has recently been shown to be an indicator of poor prognosis in cancer patients.},
  author       = {Lascorz, Jess and Bevier, Melanie and v. Schoenfels, Witigo and Kalthoff, Holger and Aselmann, Heiko and Beckmann, Jan and Egberts, Jan and Buch, Stephan and Becker, Thomas and Schreiber, Stefan and Hampe, Jochen and Hemminki, Kari and Schafmayer, Clemens and Försti, Asta},
  issn         = {1432-1262},
  keyword      = {CD47,Colorectal cancer,Extracellular matrix,Prognosis,Survival},
  language     = {eng},
  number       = {2},
  pages        = {173--181},
  publisher    = {Springer},
  series       = {International Journal of Colorectal Disease},
  title        = {Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer},
  url          = {http://dx.doi.org/10.1007/s00384-012-1541-4},
  volume       = {28},
  year         = {2013},
}