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Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic- and cryo therapy employing laser-Doppler imaging

Enejder, Annika M K; Wang, Ingrid; af Klinteberg, Claes; Andersson-Engels, Stefan LU ; Bendsöe, Niels LU ; Svanberg, Sune LU and Svanberg, Katarina LU (2000) In Acta Dermato-Venereologica 80(1). p.19-23
Abstract
Superficial blood perfusion mas monitored using laser-Doppler perfusion imaging in connection with a phase LII clinical trial comparing photodynamic therapy, utilizing topically applied aminoleuvlinic acid, with cryotherapy of basal cell, carcinomas. A total of 526 images mere recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhibited a blood perfusion 3+/-2 times that in normal tissue. Both treatment modalities induced an increased blood perfusion inside the lesions, which slowly approached normal values in conjunction with successful treatments. The blood perfusion in successfully treated lesions approached normal values 2 months after photodynamic therapy, and about 1... (More)
Superficial blood perfusion mas monitored using laser-Doppler perfusion imaging in connection with a phase LII clinical trial comparing photodynamic therapy, utilizing topically applied aminoleuvlinic acid, with cryotherapy of basal cell, carcinomas. A total of 526 images mere recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhibited a blood perfusion 3+/-2 times that in normal tissue. Both treatment modalities induced an increased blood perfusion inside the lesions, which slowly approached normal values in conjunction with successful treatments. The blood perfusion in successfully treated lesions approached normal values 2 months after photodynamic therapy, and about 1 year after cryotherapy, The tissue perfusion in recurrent lesions did not decrease to normal values after the treatment, suggesting that the laser-Doppler perfusion imaging technique can be used to follow the healing process and discover possible persistent tumour growth. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laser-Doppler flowmetry, aminolevulinic acid, photochemotherapy, basal cell, carcinoma, perfusion, regional
in
Acta Dermato-Venereologica
volume
80
issue
1
pages
19 - 23
publisher
Medical Journals Limited
ISSN
1651-2057
language
English
LU publication?
yes
id
86bd0658-d46d-4d5d-8deb-b22ac70da61c (old id 35073)
alternative location
http://openurl.ingenta.com/content?genre=article&issn=0001-5555&volume=80&issue=1&spage=19&epage=23
date added to LUP
2007-06-20 16:34:43
date last changed
2016-04-16 04:51:36
@article{86bd0658-d46d-4d5d-8deb-b22ac70da61c,
  abstract     = {Superficial blood perfusion mas monitored using laser-Doppler perfusion imaging in connection with a phase LII clinical trial comparing photodynamic therapy, utilizing topically applied aminoleuvlinic acid, with cryotherapy of basal cell, carcinomas. A total of 526 images mere recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhibited a blood perfusion 3+/-2 times that in normal tissue. Both treatment modalities induced an increased blood perfusion inside the lesions, which slowly approached normal values in conjunction with successful treatments. The blood perfusion in successfully treated lesions approached normal values 2 months after photodynamic therapy, and about 1 year after cryotherapy, The tissue perfusion in recurrent lesions did not decrease to normal values after the treatment, suggesting that the laser-Doppler perfusion imaging technique can be used to follow the healing process and discover possible persistent tumour growth.},
  author       = {Enejder, Annika M K and Wang, Ingrid and af Klinteberg, Claes and Andersson-Engels, Stefan and Bendsöe, Niels and Svanberg, Sune and Svanberg, Katarina},
  issn         = {1651-2057},
  keyword      = {laser-Doppler flowmetry,aminolevulinic acid,photochemotherapy,basal cell,carcinoma,perfusion,regional},
  language     = {eng},
  number       = {1},
  pages        = {19--23},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic- and cryo therapy employing laser-Doppler imaging},
  volume       = {80},
  year         = {2000},
}