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A follow-up study of Nordic multiple sclerosis candidate gene regions

Datta, P. ; Harbo, H. F. ; Ryder, L. P. ; Akesson, E. ; Benedikz, J. ; Celius, E. G. ; Andersen, O. ; Myhe, K-M ; Sandberg Wollheim, Magnhild LU and Hillert, J. , et al. (2007) In Multiple Sclerosis Journal 13(5). p.584-589
Abstract
In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), DIS2627 (1p22), D6S273 (6p21.33, HLA class III) and D72S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sclerosis, Nordic countries, multiple, LID screens, HLA, genetics, candidate regions, GAMES
in
Multiple Sclerosis Journal
volume
13
issue
5
pages
584 - 589
publisher
SAGE Publications
external identifiers
  • wos:000247376100003
  • scopus:34047204808
ISSN
1477-0970
DOI
10.1177/1352458506071790
language
English
LU publication?
yes
id
35077d30-32d3-4ca1-9621-41b97940a1a4 (old id 648294)
date added to LUP
2016-04-01 12:13:41
date last changed
2020-01-12 09:26:56
@article{35077d30-32d3-4ca1-9621-41b97940a1a4,
  abstract     = {In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value &lt;0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), DIS2627 (1p22), D6S273 (6p21.33, HLA class III) and D72S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.},
  author       = {Datta, P. and Harbo, H. F. and Ryder, L. P. and Akesson, E. and Benedikz, J. and Celius, E. G. and Andersen, O. and Myhe, K-M and Sandberg Wollheim, Magnhild and Hillert, J. and Svejgaard, A. and Sorensen, P. S. and Spurkland, A. and Oturai, A.},
  issn         = {1477-0970},
  language     = {eng},
  number       = {5},
  pages        = {584--589},
  publisher    = {SAGE Publications},
  series       = {Multiple Sclerosis Journal},
  title        = {A follow-up study of Nordic multiple sclerosis candidate gene regions},
  url          = {http://dx.doi.org/10.1177/1352458506071790},
  doi          = {10.1177/1352458506071790},
  volume       = {13},
  year         = {2007},
}