Notes on quantitative susceptibility mapping reconstruction accuracy under challenging conditions: Phantom measurements and simulations
Lundberg, Anna LU ; Lind, Emelie LU ; Knutsson, Linda LU
and Wirestam, Ronnie
LU
(2022)
In Journal of Medical and Scientific Research
10(3).
p.111-117
- Abstract
- Magnetic susceptibility can be assessed by quantitative susceptibility mapping (QSM), based on measured magnetic resonance imaging (MRI) phase data. The QSM reconstruction process is, however, mathematically challenging and still not fully robust. A signal-generating holmium [Ho(III)] aqueous solution with air-equivalent magnetic susceptibility was prepared, and used as a surrounding medium in a water phantom with tubes filled with a solution of gadolinium contrast agent at various concentrations. Extended analyses under controlled conditions were accomplished by simulations of the phantom construction. Without surrounding holmium solution, a gadolinium tube positioned centrally, parallel with B0, showed a susceptibility difference that... (More)
- Magnetic susceptibility can be assessed by quantitative susceptibility mapping (QSM), based on measured magnetic resonance imaging (MRI) phase data. The QSM reconstruction process is, however, mathematically challenging and still not fully robust. A signal-generating holmium [Ho(III)] aqueous solution with air-equivalent magnetic susceptibility was prepared, and used as a surrounding medium in a water phantom with tubes filled with a solution of gadolinium contrast agent at various concentrations. Extended analyses under controlled conditions were accomplished by simulations of the phantom construction. Without surrounding holmium solution, a gadolinium tube positioned centrally, parallel with B0, showed a susceptibility difference that agreed well with theoretical values, whereas a peripheral parallel tube position showed larger deviation. Orientation perpendicular to B0 resulted in less variation between the internal tube positions. Air-equivalent magnetic susceptibility corresponded to 16.5 mM Ho(III) solution. With surrounding holmium solution, several post-processing steps became challenging. Simulations indicated higher degree of underestimation when the theoretical susceptibility difference increased. Details in the mathematical implementation, for example, background field removal can strongly influence the result. Simulated results were, in part, unexpected, and provided awareness of limitations in the reconstruction technique, mainly related to conditions with large susceptibility differences between compartments. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/35319b3e-15b0-4f35-a35b-e9f2a17b4fb5
- author
- Lundberg, Anna
LU
; Lind, Emelie
LU
; Knutsson, Linda
LU
and Wirestam, Ronnie
LU
- organization
- publishing date
- 2022-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Medical and Scientific Research
- volume
- 10
- issue
- 3
- pages
- 111 - 117
- ISSN
- 2394-112X
- DOI
- 10.17727/JMSR.2022/10-21
- language
- English
- LU publication?
- yes
- id
- 35319b3e-15b0-4f35-a35b-e9f2a17b4fb5
- date added to LUP
- 2024-02-20 09:32:17
- date last changed
- 2024-02-20 10:32:21
@article{35319b3e-15b0-4f35-a35b-e9f2a17b4fb5,
abstract = {{Magnetic susceptibility can be assessed by quantitative susceptibility mapping (QSM), based on measured magnetic resonance imaging (MRI) phase data. The QSM reconstruction process is, however, mathematically challenging and still not fully robust. A signal-generating holmium [Ho(III)] aqueous solution with air-equivalent magnetic susceptibility was prepared, and used as a surrounding medium in a water phantom with tubes filled with a solution of gadolinium contrast agent at various concentrations. Extended analyses under controlled conditions were accomplished by simulations of the phantom construction. Without surrounding holmium solution, a gadolinium tube positioned centrally, parallel with B0, showed a susceptibility difference that agreed well with theoretical values, whereas a peripheral parallel tube position showed larger deviation. Orientation perpendicular to B0 resulted in less variation between the internal tube positions. Air-equivalent magnetic susceptibility corresponded to 16.5 mM Ho(III) solution. With surrounding holmium solution, several post-processing steps became challenging. Simulations indicated higher degree of underestimation when the theoretical susceptibility difference increased. Details in the mathematical implementation, for example, background field removal can strongly influence the result. Simulated results were, in part, unexpected, and provided awareness of limitations in the reconstruction technique, mainly related to conditions with large susceptibility differences between compartments.}},
author = {{Lundberg, Anna and Lind, Emelie and Knutsson, Linda and Wirestam, Ronnie}},
issn = {{2394-112X}},
language = {{eng}},
month = {{09}},
number = {{3}},
pages = {{111--117}},
series = {{Journal of Medical and Scientific Research}},
title = {{Notes on quantitative susceptibility mapping reconstruction accuracy under challenging conditions: Phantom measurements and simulations}},
url = {{http://dx.doi.org/10.17727/JMSR.2022/10-21}},
doi = {{10.17727/JMSR.2022/10-21}},
volume = {{10}},
year = {{2022}},
}